人乳头瘤病毒相关的头颈癌发生的分子机制
Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer.
作者信息
Faraji Farhoud, Zaidi Munfarid, Fakhry Carole, Gaykalova Daria A
机构信息
Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
出版信息
Microbes Infect. 2017 Sep-Oct;19(9-10):464-475. doi: 10.1016/j.micinf.2017.06.001. Epub 2017 Jun 12.
Abstract
This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.
摘要
本综述在头颈部鳞状细胞癌（HNSCC）的背景下，研究了人乳头瘤病毒（HPV）相关致癌作用的一般细胞和分子基础，并聚焦于有特定数据可用领域的HPV阳性口咽鳞状细胞癌。它涵盖了HPV阳性HNSCC中失调的主要信号通路以及与该疾病相关的全基因组变化。
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