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TRAF3/CYLD mutations identify a distinct subset of human papillomavirus-associated head and neck squamous cell carcinoma.TRAF3/CYLD突变可鉴定出人类乳头瘤病毒相关头颈部鳞状细胞癌的一个独特亚群。
Cancer. 2017 May 15;123(10):1778-1790. doi: 10.1002/cncr.30570. Epub 2017 Mar 13.
2
Integration of high-risk human papillomavirus into cellular cancer-related genes in head and neck cancer cell lines.高危型人乳头瘤病毒整合至头颈癌细胞系的细胞癌相关基因中。
Head Neck. 2017 May;39(5):840-852. doi: 10.1002/hed.24729. Epub 2017 Feb 25.
3
Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual.头颈部肿瘤—美国癌症联合委员会第八版癌症分期手册的重大变化。
CA Cancer J Clin. 2017 Mar;67(2):122-137. doi: 10.3322/caac.21389. Epub 2017 Jan 27.
4
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9
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Genomic alterations in human epidermal growth factor receptor 2 (HER2/ERBB2) in head and neck squamous cell carcinoma.头颈部鳞状细胞癌中人类表皮生长因子受体2（HER2/ERBB2）的基因组改变
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人乳头瘤病毒相关的头颈癌发生的分子机制

Molecular mechanisms of human papillomavirus-related carcinogenesis in head and neck cancer.

作者信息

Faraji Farhoud, Zaidi Munfarid, Fakhry Carole, Gaykalova Daria A

机构信息

Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.

Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.

出版信息

Microbes Infect. 2017 Sep-Oct;19(9-10):464-475. doi: 10.1016/j.micinf.2017.06.001. Epub 2017 Jun 12.

DOI:10.1016/j.micinf.2017.06.001
PMID:28619685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5603399/
Abstract

This review examines the general cellular and molecular underpinnings of human papillomavirus (HPV)-related carcinogenesis in the context of head and neck squamous cell carcinoma (HNSCC) and focuses on HPV-positive oropharyngeal squamous cell carcinoma in areas for which specific data is available. It covers the major pathways dysregulated in HPV-positive HNSCC and the genome-wide changes associated with this disease.

摘要

本综述在头颈部鳞状细胞癌（HNSCC）的背景下，研究了人乳头瘤病毒（HPV）相关致癌作用的一般细胞和分子基础，并聚焦于有特定数据可用领域的HPV阳性口咽鳞状细胞癌。它涵盖了HPV阳性HNSCC中失调的主要信号通路以及与该疾病相关的全基因组变化。