Department of Anatomy, Chonnam National University Medical School, Hwasun, Korea.
Department of Biochemistry, Chonnam National University Medical School, Hwasun, Korea.
CNS Neurosci Ther. 2021 Jun;27(6):633-642. doi: 10.1111/cns.13622. Epub 2021 Mar 1.
Depressive disorder is one of the most widespread forms of psychiatric pathology, worldwide. According to a report by the World Health Organization, the number of people with depression, globally, is increasing dramatically with each year. Previous studies have demonstrated that various factors, including genetics and environmental stress, contribute to the risk of depression. As such, it is crucial to develop a detailed understanding of the pathogenesis of depressive disorder and animal studies are essential for identifying the mechanisms and genetic disorders underlying depression. Recently, many researchers have reported on the pathology of depression via various models of depressive disorder. Given that different animal models of depression show differences in terms of patterns of depressive behavior and pathology, the comparison between depressive animal models is necessary for progress in the field of the depression study. However, the various animal models of depression have not been fully compared or evaluated until now. In this paper, we reviewed the pathophysiology of the depressive disorder and its current animal models with the analysis of their transcriptomic profiles. We provide insights for selecting different animal models for the study of depression.
抑郁障碍是全世界最普遍的精神病理学形式之一。根据世界卫生组织的一份报告，全球范围内抑郁症患者的数量每年都在急剧增加。先前的研究表明，包括遗传和环境压力在内的多种因素都会增加患抑郁症的风险。因此，深入了解抑郁障碍的发病机制至关重要，而动物研究对于确定抑郁症的机制和遗传障碍至关重要。最近，许多研究人员通过各种抑郁障碍模型报告了抑郁障碍的病理学。鉴于不同的抑郁动物模型在抑郁行为和病理学模式上存在差异，因此有必要对抑郁动物模型进行比较，以推动抑郁研究领域的发展。然而，到目前为止，还没有对各种抑郁动物模型进行充分的比较或评估。在本文中，我们通过分析其转录组谱，综述了抑郁障碍的病理生理学及其目前的动物模型。我们为选择不同的动物模型来研究抑郁症提供了一些见解。
