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COVID-19 对头颈部癌症诊断和疾病程度的影响。

The impact of COVID-19 on head and neck cancer diagnosis and disease extent.

机构信息

Department of Head and Neck Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.

Department of Otorhinolaryngology - Head and Neck Surgery, Singapore General Hospital, Singapore, Singapore.

出版信息

Head Neck. 2021 Jun;43(6):1890-1897. doi: 10.1002/hed.26665. Epub 2021 Mar 2.

Abstract

BACKGROUND

Due to COVID-19, diagnostic delays and a surge of advanced head and neck cancer (HNC) is anticipated. We hereby evaluate patient and tumor characteristics before and during the early COVID-19 period.

METHODS

Retrospective review of patients with HNC presented at a multidisciplinary tumor conference from May 14, 2020 to June 18, 2020 was performed and compared to a similar 6-week period a year before. Demographics, time to diagnosis, and tumor characteristics were analyzed.

RESULTS

There was a 25% reduction in newly diagnosed malignancies. Groups were similar in baseline characteristics, duration of symptoms, and time to diagnosis. However, median primary tumor size was significantly larger (p = 0.042) and T stage more advanced for mucosal subsites (p = 0.025) in the COVID-19 group.

CONCLUSION

Our findings suggest increased tumor burden in patients with HNC presenting during the pandemic, despite a similar time to diagnosis. This may become more pronounced as the pandemic duration is extended.

摘要

背景

由于 COVID-19,预计会出现诊断延迟和头颈部癌症(HNC)的高发。在此,我们评估了 COVID-19 早期前后患者和肿瘤的特征。

方法

回顾性分析了 2020 年 5 月 14 日至 6 月 18 日在多学科肿瘤会议上就诊的 HNC 患者,并与前一年同期的类似 6 周进行了比较。分析了人口统计学、诊断时间和肿瘤特征。

结果

新诊断的恶性肿瘤减少了 25%。两组在基线特征、症状持续时间和诊断时间方面相似。然而,COVID-19 组的原发肿瘤大小中位数明显更大(p = 0.042),黏膜部位的 T 分期更晚(p = 0.025)。

结论

我们的研究结果表明,尽管诊断时间相似,但在大流行期间就诊的 HNC 患者的肿瘤负担增加。随着大流行时间的延长,这种情况可能会更加明显。

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