Postgraduate Program in Microbiology and Parasitology, Department of Microbiology and Parasitology, Federal University of Pelotas (UFPel), Pelotas, Rio Grande do Sul, Brazil.
Postgraduate Program in Health Sciences - Parasitology Laboratory, Federal University of Rio Grande (FURG), Academic Area of the University Hospital,Rio Grande, Rio Grande do Sul, Brazil.
J Helminthol. 2021 Mar 2;95:e11. doi: 10.1017/S0022149X20001030.
Probiotics have been shown to reduce the intensity of Toxocara canis infection in mice. However, larval transmission of this nematode also occurs via transplacental and transmammary routes. Thus, the aim of this study was to evaluate the effect of the Saccharomyces boulardii probiotic on the vertical transmission of T. canis in Swiss mice. The mice received 107S. boulardii colony-forming units per gram of food. The supplementation began 15 days before mating and was maintained throughout pregnancy and lactation. The animals were inoculated with 300 T. canis embryonated eggs on the 14th day of pregnancy. The presence of larvae was examined in the organs of the females and their offspring. The examined organs included the following: brain, liver, lungs, heart, kidneys, spleen, eye, skeletal muscle (carcass) and mammary glands of lactating females. There was a 42% (P = 0.041) reduction in the number of larvae transmitted to offspring in the group that received probiotic-supplemented food (GI). Additionally, there was a 50% reduction (P = 0.023) in the number of larvae found in the brains of lactating offspring in the GI group. These results reveal the potential of S. boulardii probiotic use as an auxiliary method of controlling visceral toxocariasis.
益生菌已被证明可降低小鼠感染犬弓蛔虫的强度。然而，这种线虫的幼虫也可通过胎盘和乳腺途径传播。因此，本研究旨在评估酿酒酵母布拉氏酵母菌益生菌对瑞士小鼠感染犬弓蛔虫垂直传播的影响。小鼠接受每克食物 107 个酿酒酵母布拉氏酵母菌集落形成单位。补充剂在交配前 15 天开始，并在整个怀孕期间和哺乳期维持。在妊娠第 14 天，动物被接种 300 个犬弓蛔虫胚胎卵。检查雌性及其后代的器官中幼虫的存在。检查的器官包括：大脑、肝脏、肺、心脏、肾脏、脾脏、眼睛、骨骼肌（躯体）和哺乳期雌性的乳腺。在接受益生菌补充食物（GI）的组中，向后代传播的幼虫数量减少了 42%（P = 0.041）。此外，在 GI 组中，哺乳期后代大脑中的幼虫数量减少了 50%（P = 0.023）。这些结果表明，使用酿酒酵母布拉氏酵母菌益生菌作为控制内脏旋毛虫病的辅助方法具有潜力。
