近年来含苯并环庚烷结构的天然产物全合成研究进展
Recent advances in total syntheses of natural products containing the benzocycloheptane motif.
机构信息
Institute of Chinese Medical Sciences, University of Macau, Macau, China.
Shenzhen Grubbs Institute and Department of Chemistry, Guangdong Provincial Key Laboratory of Catalysis, Southern University of Science and Technology, Shenzhen 518055, China.
出版信息
Nat Prod Rep. 2021 Oct 20;38(10):1821-1851. doi: 10.1039/d1np00003a.
Covering: 2010 to 2020Benzocycloheptane is a fundamental and unique structural motif found in pharmaceuticals and natural products. The total syntheses of natural products bearing the benzocycloheptane subunit are challenging and there are only a few efficient approaches to access benzocycloheptane. Thus, new methods and innovative strategies for preparing such natural products need to be developed. In this review, recent progress in the total syntheses of natural products bearing the benzocycloheptane motif is presented, and key transformations for the construction of benzocycloheptane are highlighted. This review provides a useful guide for those engaged in the syntheses of natural products containing the benzocycloheptane motif.
涵盖时间
2010 年至 2020 年苯并环庚烷是药物和天然产物中基本且独特的结构基序。含有苯并环庚烷亚基的天然产物的全合成具有挑战性，只有少数有效的方法可以获得苯并环庚烷。因此，需要开发制备此类天然产物的新方法和创新策略。在本文综述中，介绍了含有苯并环庚烷结构基序的天然产物的全合成的最新进展，并强调了构建苯并环庚烷的关键转化。本文综述为从事含有苯并环庚烷结构基序的天然产物合成的人员提供了有用的指导。
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