Jung You Jin, Ro Young Suck, Ryu Hwa Jung, Kim Jeong Eun
Department of Dermatology, Hanyang University College of Medicine, Seoul, Korea.
Department of Dermatology, Korea University Ansan Hospital, Ansan, Korea.
J Cosmet Laser Ther. 2020 Jul 3;22(4-5):205-209. doi: 10.1080/14764172.2021.1880599. Epub 2021 Mar 2.
Facial erythema from rosacea and acne is one of the most common problems encountered in dermatologic clinics. Effective therapeutic interventions for persistent erythema, which can cause patients frustration and psychological distress, are needed. The aim of this study was to evaluate the efficacy and safety of an invasive short pulsed-type bipolar radiofrequency device (IPBRF) for the treatment of intractable facial erythema. Thirty-one patients who had been diagnosed with rosacea or acne vulgaris and combined erythema underwent at least two IPBRF treatment sessions (maximum: 5) at 2-week intervals. Treatment outcomes were evaluated by investigator global assessment (IGA) based on clinical photographs, patient global assessment (PGA) score, and skin biophysical parameters including erythema index (EI), melanin index (MI), and transepidermal water loss (TEWL). Most patients showed significant clinical improvement. IGA scores for erythema, pores and smoothness improved after treatment. PGA also showed a trend toward improvement. Mean EI was significantly improved after the second treatment compared to baseline, which maintained until the study period. MI and TEWL showed a tendency toward improvement. There were no serious adverse events reported during the study. IPBRF led to rapid clinical improvement in facial erythema associated with rosacea and acne vulgaris and could be an effective and safe treatment option.
酒渣鼻和痤疮引起的面部红斑是皮肤科诊所最常见的问题之一。对于可能导致患者沮丧和心理困扰的持续性红斑，需要有效的治疗干预措施。本研究的目的是评估一种侵入性短脉冲型双极射频设备（IPBRF）治疗顽固性面部红斑的疗效和安全性。31例被诊断为酒渣鼻或寻常痤疮合并红斑的患者，每隔2周接受至少2次IPBRF治疗（最多5次）。通过基于临床照片的研究者整体评估（IGA）、患者整体评估（PGA）评分以及包括红斑指数（EI）、黑色素指数（MI）和经表皮水分流失（TEWL）在内的皮肤生物物理参数来评估治疗效果。大多数患者显示出显著的临床改善。治疗后红斑、毛孔和光滑度的IGA评分有所改善。PGA也显示出改善的趋势。与基线相比，第二次治疗后平均EI显著改善，并持续到研究期结束。MI和TEWL有改善的趋势。研究期间未报告严重不良事件。IPBRF可使酒渣鼻和寻常痤疮相关的面部红斑迅速得到临床改善，可能是一种有效且安全的治疗选择。
