Wei Bing, Lu Jun
School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Department of Orthopaedic Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu, China.
Stem Cell Rev Rep. 2021 Oct;17(5):1534-1551. doi: 10.1007/s12015-021-10143-9. Epub 2021 Mar 2.
The natural healing ability of tendon is limited, and it cannot restore the native structure and function of tendon injuries. Tendon-derived stem cells (TDSCs) are a new type of pluripotent stem cells with multi-directional differentiation potential and are expected to become a promising cell-seed for the treatment of tendon injuries in the future. In this review, we outline the latest advances in the culture and identification of TDSCs. In addition, the influencing factors on the differentiation of TDSCs are discussed. Moreover, we aim to discuss recent studies to enhance TDSCs treatment of injured tendons. Finally, we identify the limitations of the current understanding of TDSCs biology, the main challenges of using their use, and potential therapeutic strategies to inform cell-based tendon repair.
肌腱的自然愈合能力有限，无法恢复肌腱损伤的原始结构和功能。肌腱来源的干细胞（TDSCs）是一类具有多向分化潜能的新型多能干细胞，有望在未来成为治疗肌腱损伤的有前景的细胞种子。在这篇综述中，我们概述了TDSCs培养和鉴定的最新进展。此外，还讨论了影响TDSCs分化的因素。而且，我们旨在探讨近期增强TDSCs治疗损伤肌腱的研究。最后，我们明确了当前对TDSCs生物学理解的局限性、使用它们的主要挑战以及基于细胞的肌腱修复的潜在治疗策略。
