UK Centre for Tobacco and Alcohol Studies, Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, Nottingham City Hospital, Nottingham, UK.
SPECTRUM Consortium, UK.
Addiction. 2021 Sep;116(9):2521-2528. doi: 10.1111/add.15463. Epub 2021 Mar 22.
To analyse content and emission data submitted by manufacturers for nicotine-containing vaping products in the United Kingdom (UK) in accordance with the European Union Tobacco Products Directive.
Analysis of ingredient and emission data reported for all e-liquid-containing e-cigarettes, cartridges or refill containers notified to the Medicines and Healthcare Regulatory Agency (MHRA) from November 2016 to October 2017.
United Kingdom CASES: A total of 40 785 e-liquid containing products.
The average number of ingredients per product, nicotine concentrations, frequency of occurrence ingredients and frequency and levels of chemical emissions.
Reports were not standardised in relation to units of measurement or constituent nomenclature. Products listed an average of 17 ingredients and 3.3% were reported not to contain nicotine. A total of 59% of products contained <12 mg nicotine per mL, and <1% were reported to have nicotine concentrations above the legal limit of 20 mg/mL. Over 1500 ingredients were reported, and other than nicotine the most commonly reported non-flavour ingredients were propylene glycol (97% of products) and glycerol (71%). The most common flavour ingredients were ethyl butyrate (42%), vanillin (35%) and ethyl maltol (33%). The most frequently reported chemical emissions were nicotine (65%), formaldehyde (48%) and acetaldehyde (40%). The reporting of the concentration of emissions was not standardised; emissions were reported in a format allowing analysis of median estimated concentration for between 13% and 100% of products for each reported emission. Most of the frequently reported emissions, other than nicotine, were present in median estimated concentrations below 1 μg/L of inspired air, and with the exception of nicotine, acrolein and diacetyl, at median levels below European Chemicals Agency Long Term Exposure and United States (US) Department of Labor Occupational Safety and Health Administration (OSHA) limits, where these were available.
An analysis of reports to the United Kingdom's Medicines and Healthcare products Regulatory Agency by manufacturers of vaping products shows that (i) these products have a large range of ingredients and emissions, (ii) the reporting system is unstandardized in terms of reporting requirements, and (iii) for quantified emissions, median levels are for the most part below published safe limits for ambient air.
根据欧盟烟草制品指令，分析英国（英国）制造商提交的含尼古丁蒸气产品的成分和排放数据。
对 2016 年 11 月至 2017 年 10 月向药品和保健产品监管局（MHRA）通报的所有含电子烟液的电子烟、墨盒或补充容器的成分和排放数据进行分析。
英国
共 40785 种含电子烟液产品。
每种产品的平均成分数、尼古丁浓度、出现成分的频率以及化学排放物的频率和水平。
报告在测量单位或成分命名方面没有标准化。产品列出的平均成分 17 种，有 3.3%的产品报告不含尼古丁。共有 59%的产品每毫升含有<12 毫克尼古丁，<1%的产品报告尼古丁浓度超过 20 毫克/毫升的法定限制。报告了超过 1500 种成分，除尼古丁外，最常见的非香料成分是丙二醇（97%的产品）和甘油（71%）。最常见的香料成分是丁酸乙酯（42%）、香草醛（35%）和乙基麦芽酚（33%）。报告的最常见化学排放物是尼古丁（65%）、甲醛（48%）和乙醛（40%）。排放物报告的浓度未标准化；排放物以允许分析每种报告排放物 13%至 100%产品的中位数估计浓度的格式报告。除尼古丁外，大多数经常报告的排放物以吸入空气的中位数估计浓度低于 1μg/L 存在，除尼古丁、丙烯醛和双乙酰外，在欧洲化学品管理局长期暴露和美国（美国）劳工部职业安全与健康管理局（OSHA）规定的限度以下，只要这些规定可用。
对英国药品和保健产品监管局收到的蒸气产品制造商报告的分析表明，（i）这些产品有很大范围的成分和排放物，（ii）报告系统在报告要求方面没有标准化，以及（iii）对于量化排放物，中位数水平在大多数情况下低于公布的环境空气安全限值。
Zotero 插件