Department of Plastic and Burn Surgery, National Key Clinical Construction Specialty, Wound Repair and Regeneration Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Skin Res Technol. 2021 Sep;27(5):789-796. doi: 10.1111/srt.13020. Epub 2021 Mar 2.
This study used laser speckle contrast imaging (LSCI) to evaluate the difference in blood perfusion between hypertrophic scars and keloids.
A total of 30 keloids, 21 early hypertrophic scars, 20 proliferative hypertrophic scars, 20 regressive hypertrophic scars, and 20 mature hypertrophic scars were enrolled into this study. Vancouver Scar Scale (VSS) was assessed by a plastic surgeon. LSCI was used to evaluate perfusion of the whole (W), marginal (M), central (C) regions, and surrounding normal skin of the scars, and ratios (M/N, C/N) were calculated.
The perfusion of the marginal region in the keloid was significantly higher than that of the central region. Nevertheless, there was no significant difference in perfusion between the central and marginal regions in the early, proliferative, regressive, and mature hypertrophic scars. The degree of perfusion and perfusion ratio in the marginal region of keloid was similar to that of proliferative hypertrophic scars, and the degree of perfusion and perfusion ratio in central region of keloid group was similar to that of early and regressive hypertrophic scars.
The difference in perfusion distribution in keloids and hypertrophic scars may provide ideas for their identification. LSCI may be a useful method for differentiating between keloids and hypertrophic scars.
本研究采用激光散斑对比成像（LSCI）评估增生性瘢痕和瘢痕疙瘩之间的血液灌注差异。
共纳入 30 例瘢痕疙瘩、21 例早期增生性瘢痕、20 例增殖性增生性瘢痕、20 例退行性增生性瘢痕和 20 例成熟增生性瘢痕。由整形外科医生评估温哥华瘢痕量表（VSS）。使用 LSCI 评估整个（W）、边缘（M）、中央（C）区域以及瘢痕周围正常皮肤的灌注，并计算比值（M/N、C/N）。
瘢痕疙瘩的边缘区域的灌注明显高于中央区域。然而，早期、增殖性、退行性和成熟增生性瘢痕的中央和边缘区域之间的灌注无明显差异。瘢痕疙瘩边缘区域的灌注程度和灌注比值与增殖性增生性瘢痕相似，瘢痕疙瘩中央区域的灌注程度和灌注比值与早期和退行性增生性瘢痕相似。
瘢痕疙瘩和增生性瘢痕之间的灌注分布差异可能为其鉴别提供思路。LSCI 可能是鉴别瘢痕疙瘩和增生性瘢痕的一种有用方法。
