Departments of Breast Surgery.
Plastic and Reconstructive Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Dermatol Surg. 2021 Apr 1;47(4):e117-e121. doi: 10.1097/DSS.0000000000002836.
Most of the widely used methods for the assessment of keloid treatment are subjective grading scales based on the opinion of an individual clinician or patient. There is a growing need for objective methods to evaluate keloid treatment.
This study aimed to evaluate the value of laser speckle contrast imaging (LSCI) as an objective method for the assessment of dual-wavelength laser therapy for keloids.
This prospective study included 21 patients with 54 keloids. All patients were treated with a combined 585-nm pulsed dye laser and 1,064 nm neodymium-doped yttrium aluminum garnet dual-wavelength laser at 4 weeks to 6 weeks intervals. Keloids were assessed using the Vancouver Scar Scale (VSS) and LSCI.
The total VSS score significantly decreased after 4 sessions of treatment (p < .05). Blood perfusion in keloids as measured by LSCI was significantly reduced after treatment (p < .05). The improvement of chest keloids in terms of the total VSS score and blood perfusion was significantly greater than that of scapular keloids (p < .05). There was a positive correlation between decreased perfusion and reduced total VSS score (R2 = 0.84).
Blood perfusion in keloids significantly decreased after dual-wavelength laser therapy. Laser speckle contrast imaging is a promising objective method for assessing the improvement of keloids treated with laser therapy.
评估瘢痕疙瘩治疗效果的常用方法大多是基于临床医生或患者个人意见的主观分级量表。人们越来越需要客观的方法来评估瘢痕疙瘩的治疗效果。
本研究旨在评估激光散斑对比成像（LSCI）作为评估双波长激光治疗瘢痕疙瘩的客观方法的价值。
这项前瞻性研究纳入了 21 名 54 处瘢痕疙瘩患者。所有患者均在 4 至 6 周的时间间隔内接受 585nm 脉冲染料激光和 1064nm 掺钕钇铝石榴石双波长激光联合治疗。采用温哥华瘢痕量表（VSS）和 LSCI 对瘢痕疙瘩进行评估。
经过 4 次治疗后，总 VSS 评分显著降低（p <.05）。LSCI 测量的瘢痕疙瘩内血液灌注明显减少（p <.05）。与肩胛部瘢痕疙瘩相比，胸部瘢痕疙瘩的总 VSS 评分和血液灌注改善更显著（p <.05）。灌注减少与总 VSS 评分降低呈正相关（R2 = 0.84）。
双波长激光治疗后，瘢痕疙瘩内的血液灌注明显减少。激光散斑对比成像（LSCI）是评估激光治疗后瘢痕疙瘩改善的一种很有前途的客观方法。
