Key Laboratory of Carcinogenesis and Invasion, Chinese Ministry of Education, Department of Radiology, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, PR China; Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, 410078, PR China; Key Laboratory of Carcinogenesis, Chinese Ministry of Health, Changsha, Hunan, 410078, PR China.
The Hormel Institute, University of Minnesota, Austin, MN, 55912, USA.
Eur J Pharmacol. 2021 May 5;898:173972. doi: 10.1016/j.ejphar.2021.173972. Epub 2021 Feb 27.
Dehydrogenase/reductase member 2 (DHRS2) belongs to the short-chain dehydrogenase/reductase (SDR) family. It was initially isolated from the nuclear extract of hepatocellular carcinoma HepG2 cells and was identified as a specific cell cycle regulator. DHRS2 is a reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent carbonyl reductase and catalyzes the reduction of dicarbonyl compounds. It is also functionally active in lipid metabolism and acts as a metabolic enzyme of hormones. Recent studies have shown that DHRS2 reprograms lipid metabolism and redox homeostasis to regulate proliferation, migration, invasion, and drug resistance of cancer cells. Here, we describe the structure, organelle localization and function of DHRS2, and also highlight its roles in the pathologic progression of diseases.
脱氢酶/还原酶成员 2（DHRS2）属于短链脱氢酶/还原酶（SDR）家族。它最初是从肝癌 HepG2 细胞的核提取物中分离出来的，被鉴定为一种特定的细胞周期调节剂。DHRS2 是一种还原型烟酰胺腺嘌呤二核苷酸磷酸（NADPH）依赖性羰基还原酶，可催化二羰基化合物的还原。它在脂质代谢中也具有功能活性，并作为激素的代谢酶。最近的研究表明，DHRS2 重新编程脂质代谢和氧化还原稳态，以调节癌细胞的增殖、迁移、侵袭和耐药性。在这里，我们描述了 DHRS2 的结构、细胞器定位和功能，并强调了它在疾病病理进展中的作用。
