九种新的二萜类化合物从 Dicapetalum gelonioides（Roxb.）Engl. 的嫩枝中分离得到。
Nine new dichapetalin-type triterpenoids from the twigs of Dichapetalum gelonioides (Roxb.) Engl.
机构信息
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
Department of Pharmaceutical Science, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Beijing 100730, PR China.
出版信息
Fitoterapia. 2021 Jun;151:104868. doi: 10.1016/j.fitote.2021.104868. Epub 2021 Feb 27.
Nine previously undescribed dichapetalin-type triterpenoids (1-9), along with 12 reported compounds (10-21), were isolated from the twigs of Dichapetalum gelonioides. Their chemical structures were mainly elucidated by comprehensive analysis of HRMS, 1D and 2D NMR spectroscopic data. The absolute configuration of compound 1 was further determined based on single-crystal X-ray diffraction. In addition, a part of compounds were evaluated the effects of inhibitory NO production in LPS-induced RAW264.7 macrophages.
从短序崖摩的嫩枝中分离得到了 9 个以前未描述的二萜化合物（1-9）和 12 个已知化合物（10-21）。通过 HRMS、1D 和 2D NMR 光谱数据分析，主要阐明了它们的化学结构。根据单晶 X 射线衍射进一步确定了化合物 1 的绝对构型。此外，部分化合物评价了其对 LPS 诱导的 RAW264.7 巨噬细胞中抑制 NO 产生的作用。
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