Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
Beijing Key Laboratory of Bioactive Substances and Functional Foods, Beijing Union University, Beijing 100191, China.
Fitoterapia. 2021 Sep;153:104982. doi: 10.1016/j.fitote.2021.104982. Epub 2021 Jun 26.
Five norursane-type triterpenoids, including three novel of 3β-28-norursa-12,17,19,21-tetraene-3-ol (1), 3β-28-norursa-12,20(30)-dien-3-ol (2) and 3β-28-norursa-12,16,20(30)-triene-3-ol (3), as well as two known 3β-28-norursa-17,19,21-trien-3-ol (4) and 3β-28-norursa-12-ene-3-ol (5) were isolated from the ethyl acetate dissolved fraction of the ethanol extract from Rosmarinus officinalis. Their structures were elucidated by HR-ESI-MS, IR, 1D- and 2D-NMR spectroscopic methods. Compounds 1-5 exhibited significant inhibitory effect on NO production in LPS-activated RAW264.7 cells, and compounds 2, 3 and 5 shown better anti-inflammatory activity.
从迷迭香乙醇提取物的乙酸乙酯溶解部分中分离得到五种熊果酸型三萜，包括三种新的 3β-28-降乌苏-12,17,19,21-四烯-3-醇（1）、3β-28-降乌苏-12,20(30)-二烯-3-醇（2）和 3β-28-降乌苏-12,16,20(30)-三烯-3-醇（3），以及两种已知的 3β-28-降乌苏-17,19,21-三烯-3-醇（4）和 3β-28-降乌苏-12-烯-3-醇（5）。它们的结构通过高分辨电喷雾质谱（HR-ESI-MS）、红外光谱（IR）、1D-和 2D-NMR 波谱学方法阐明。化合物 1-5 对 LPS 激活的 RAW264.7 细胞中的 NO 产生具有显著的抑制作用，化合物 2、3 和 5 显示出更好的抗炎活性。
