来自长柄山蒟的地枫皮型三萜及其抗炎活性。
Dichapetalin-type triterpenoids from Dichapetalum longipetalum and their anti-inflammatory activity.
机构信息
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin 300070, PR China.
School of Pharmacy, Hainan Medical University, Haikou, Hainan, 571199, PR China.
出版信息
Phytochemistry. 2024 Jan;217:113900. doi: 10.1016/j.phytochem.2023.113900. Epub 2023 Oct 28.
A phytochemical research on the twigs of Dichapetalum longipetalum (Turcz.) Engl. Resulted in five undescribed dichapetalin-type triterpenoids 1-5. Their chemical structures were determined by spectroscopic analysis of HR-ESIMS and NMR spectra and the absolute configuration of compound 1 was completely elucidated by single crystal X-ray crystallography. Through preliminary anti-inflammatory activity assessment, compound 1 exhibited inhibitory effect on LPS-induced NO production in RAW264.7 murine macrophages with an IC value of 2.09 μM.
对长柄山蜡树（Turcz.） Engl. 小枝的植物化学研究产生了五个未描述的双柏醇型三萜 1-5。通过高分辨电喷雾电离质谱（HR-ESIMS）和 NMR 光谱的光谱分析确定了它们的化学结构，并且通过单晶 X 射线晶体学完全阐明了化合物 1 的绝对构型。通过初步的抗炎活性评估，化合物 1 在 LPS 诱导的 RAW264.7 鼠巨噬细胞中显示出对 NO 产生的抑制作用，IC 值为 2.09 μM。
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