Department of Neurology, Charité Universitätsmedizin Berlin, Germany; Department of Education and Psychology, Freie Universität Berlin, Germany; Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Austria.
Neuroimage. 2021 May 15;232:117917. doi: 10.1016/j.neuroimage.2021.117917. Epub 2021 Feb 27.
Given the importance of emotion regulation in affective disorders, emotion regulation is at the focus of attempts to identify brain biomarkers of disease risk, treatment response, and brain development. However, to be useful as an indicator for individual characteristics of brain functions - particularly as a biomarker in a clinical context - ensuring reliability is a key challenge. Here, we systematically evaluated test-retest reliability of task-based functional magnetic resonance imaging (fMRI) activity within neural networks associated with emotion generation and regulation across three sessions. Acquiring fMRI data at ultra-high field (7T), we examined region- and voxel-wise test-retest reliability of brain activity in response to a well-established emotion regulation task for predefined region-of-interests (ROIs) implicated in four neural networks. Test-retest reliability varied considerably across the emotion regulation networks and respective ROIs. However, core emotion regulation regions, including the ventrolateral and dorsolateral prefrontal cortex (vlPFC and dlPFC) as well as the middle temporal gyrus (MTG) showed high reliability. Our findings thus support the role of these prefrontal and temporal regions as promising candidates for the study of individual differences in emotion regulation as well as for neurobiological biomarkers in clinical neuroscience research.
鉴于情绪调节在情感障碍中的重要性，情绪调节是识别疾病风险、治疗反应和大脑发育的脑生物标志物的重点。然而，要作为脑功能个体特征的指标（特别是在临床环境中作为生物标志物），确保可靠性是一个关键挑战。在这里，我们在三个会话中系统地评估了与情绪产生和调节相关的神经网络中基于任务的功能磁共振成像 (fMRI) 活动的测试 - 重测可靠性。通过在超高场 (7T) 采集 fMRI 数据，我们检查了针对四个神经网络中涉及的预先确定的感兴趣区域 (ROI) 的经过充分验证的情绪调节任务的大脑活动的区域和体素测试 - 重测可靠性。情绪调节网络和各自的 ROI 之间的测试 - 重测可靠性差异很大。然而，核心情绪调节区域，包括腹外侧和背外侧前额叶皮层 (vlPFC 和 dlPFC) 以及中颞回 (MTG)，表现出高度的可靠性。因此，我们的研究结果支持这些前额叶和颞叶区域作为研究情绪调节个体差异以及临床神经科学研究中神经生物学生物标志物的有前途的候选者的作用。
