Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand; Dental Stem Cell Biology Research Unit, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand; Division of Molecular and Regenerative Prosthodontics, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan.
Department of Anatomy, Faculty of Dentistry, Chulalongkorn University, Bangkok, 10330, Thailand.
Arch Oral Biol. 2021 May;125:105092. doi: 10.1016/j.archoralbio.2021.105092. Epub 2021 Feb 24.
Mechanical stimulation regulates many cell responses. The present study describes the effects of different in vitro mechanical stimulation approaches on stem cell behavior.
The narrative review approach was performed. The articles published in English language that addressed the effects of mechanical force on stem cells were searched on Pubmed and Scopus database. The effects of extrinsic mechanical force on stem cell response was reviewed and discussed.
Cells sense mechanical stimuli by the function of mechanoreceptors and further transduce force stimulation into intracellular signaling. Cell responses to mechanical stimuli depend on several factors including type, magnitude, and duration. Further, similar mechanical stimuli exhibit distinct cell responses based on numerous factors including cell type and differentiation stage. Various mechanical applications modulate stemness maintenance and cell differentiation toward specific lineages.
Mechanical force application modulates stemness maintenance and differentiation. Modification of force regimens could be utilized to precisely control appropriate stem cell behavior toward specific applications.
机械刺激调节许多细胞反应。本研究描述了不同体外机械刺激方法对干细胞行为的影响。
采用叙述性综述方法。在 Pubmed 和 Scopus 数据库中检索了探讨机械力对干细胞影响的英文文献。综述并讨论了外源性机械力对干细胞反应的影响。
细胞通过机械感受器的功能感知机械刺激，并将力刺激进一步转导为细胞内信号。细胞对机械刺激的反应取决于多种因素，包括类型、大小和持续时间。此外，基于许多因素，如细胞类型和分化阶段，类似的机械刺激会表现出不同的细胞反应。各种机械应用可调节干性维持和细胞向特定谱系的分化。
机械力应用调节干性维持和分化。可以通过改变力方案来精确控制特定应用中适当的干细胞行为。
