Lin Qiyuan, Yang Zhen, Xu Hao, Niu Yudi, Meng Qingchen, Xing Dan
Arthritis Clinical and Research Center, Peking University People's Hospital, No.11 Xizhimen South Street, Beijing 100044, China.
Arthritis Institute, Peking University, Beijing 100044, China.
Biomedicines. 2024 Aug 29;12(9):1963. doi: 10.3390/biomedicines12091963.
Stem cells are widely used in scientific research because of their ability to self-renew and differentiate into a variety of specialized cell types needed for body functions. However, the self-renewal and differentiation of stem cells are regulated by various stimuli, with mechanical stimulation being particularly notable due to its ability to mimic the physical environment in the body. This study systematically collected 2638 research papers published between 1994 and 2024, employing tools such as VOSviewer, CiteSpace, and GraphPad Prism to uncover research hotspots, publication trends, and collaboration networks. The results indicate a yearly increase in global research on the shear stress stimulation of stem cells, with significant contributions from the United States and China in terms of research investment and output. Future research directions include a deeper understanding of the mechanisms underlying mechanical stimulation's effects on stem cell differentiation, the development of new materials and scaffold designs to better replicate the natural cellular environment, and advancements in regenerative medicine. Despite considerable progress, challenges remain in translating basic research findings into clinical applications.
干细胞因其自我更新能力以及分化为身体功能所需的多种特化细胞类型的能力而被广泛应用于科学研究。然而，干细胞的自我更新和分化受多种刺激调控，其中机械刺激尤为显著，因为它能够模拟体内的物理环境。本研究系统收集了1994年至2024年间发表的2638篇研究论文，使用VOSviewer、CiteSpace和GraphPad Prism等工具来揭示研究热点、发表趋势和合作网络。结果表明，全球关于干细胞剪切应力刺激的研究逐年增加，美国和中国在研究投入和产出方面做出了重大贡献。未来的研究方向包括更深入地了解机械刺激对干细胞分化影响的潜在机制，开发新材料和支架设计以更好地复制天然细胞环境，以及再生医学的进展。尽管取得了相当大的进展，但将基础研究成果转化为临床应用仍面临挑战。
