Baumann G, Shaw M A
Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611.
Biochem Biophys Res Commun. 1988 Apr 29;152(2):573-8. doi: 10.1016/s0006-291x(88)80076-7.
We probed the (immunochemical) relationship between the recently discovered growth hormone binding protein in human plasma and the growth hormone receptor using monoclonal and polyclonal antibodies raised against rabbit liver growth hormone receptor. The human binding protein was recognized by these antibodies; its immunological crossreactivity compared to the rabbit receptor was 1-2%. These data suggest a) that the binding protein and the receptor are structurally related and b) that rabbit and human growth hormone receptors share some but not all epitopes.
我们使用针对兔肝生长激素受体产生的单克隆抗体和多克隆抗体，探究了人血浆中最近发现的生长激素结合蛋白与生长激素受体之间的（免疫化学）关系。这些抗体识别出了人结合蛋白；与人结合蛋白相比，其与兔受体的免疫交叉反应性为1%-2%。这些数据表明：a）结合蛋白与受体在结构上相关；b）兔和人生长激素受体有一些共同的表位，但并非全部相同。
