Public Health England, Centre for Radiation, Chemical and Environmental Hazards, Chilton, Didcot, Oxon, United Kingdom.
Department of Biosciences, University of Durham, Mountjoy Science Site, Durham DH13LE, United Kingdom.
Radiat Res. 2022 Jan 1;197(1):36-42. doi: 10.1667/RADE-20-00264.1.
Epidemiological studies suggest an increased incidence and risk of cataract after low-dose (<2 Gy) ionizing radiation exposures. However, the biological mechanism(s) of this process are not fully understood. DNA damage and repair are thought to have a contributing role in radiation-induced cataractogenesis. Recently we have reported an inverse dose-rate effect, as well as the low-dose response, of DNA damage and repair in lens epithelial cells (LECs). Here, we present further initial findings from two mutated strains (Ercc2+/- and Ptch1+/-) of mice, both reportedly susceptible to radiation-induced cataract, and their DNA damage and repair response to low-dose and low-dose-rate gamma rays. Our results support the hypothesis that the lens epithelium responds differently to radiation than other tissues, with reported radiation susceptibility to DNA damage not necessarily translating to the LECs. Genetic predisposition and strain(s) of mice have a significant role in radiation-induced cataract susceptibility.
流行病学研究表明，低剂量（<2 戈瑞）电离辐射暴露后白内障的发病率和风险增加。然而，这一过程的生物学机制尚不完全清楚。人们认为，DNA 损伤和修复在放射性白内障的发生中起了一定的作用。最近，我们报道了晶状体上皮细胞（LEC）中 DNA 损伤和修复的逆剂量率效应以及低剂量反应。在这里，我们提出了两个突变株（Ercc2+/-和Ptch1+/-）的老鼠的进一步初步研究结果，这两个突变株均易受辐射诱导的白内障影响，以及它们对低剂量和低剂量率伽马射线的 DNA 损伤和修复反应。我们的研究结果支持了这样一种假说，即晶状体上皮细胞对辐射的反应不同于其他组织，报告的对 DNA 损伤的辐射敏感性不一定转化为 LEC。遗传易感性和老鼠的品系在辐射诱导的白内障易感性中起着重要作用。
