磁性尿激酶：将尿激酶靶向纤维蛋白凝块
Magnetic urokinase: targeting of urokinase to fibrin clot.
作者信息
Yoshimoto T, Ohwada K, Takahashi K, Matsushima A, Saito Y, Inada Y
机构信息
Laboratory of Biological Chemistry, Tokyo Institute of Technology, Japan.
出版信息
Biochem Biophys Res Commun. 1988 Apr 29;152(2):739-43. doi: 10.1016/s0006-291x(88)80100-1.
A plasminogen activator of human origin, urokinase, was endowed with magnetic property. The magnetic urokinase was composed of magnetite, polyethylene glycol derivative and urokinase, and dispersed in saline. Its particle size of magnetite was approximately 30-60 nm. It was selectively delivered to fibrin clot by magnetic force in continuously circulating plasma and exerted fibrinolytic activity without degrading fibrinogen.
一种源自人类的纤溶酶原激活剂——尿激酶，被赋予了磁性。磁性尿激酶由磁铁矿、聚乙二醇衍生物和尿激酶组成，并分散于盐水中。其磁铁矿的粒径约为30 - 60纳米。在持续循环的血浆中，它通过磁力被选择性地输送至纤维蛋白凝块，并发挥纤溶活性而不降解纤维蛋白原。
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