Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Guelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON N1G 5C9, Canada.
Nutrients. 2021 Feb 26;13(3):757. doi: 10.3390/nu13030757.
Cooked common beans () improve intestinal health in lean mice and attenuate intestinal dysbiosis and inflammation when consumed concurrent with obesity development. We determined the effects of a high-fat (HF) bean supplemented diet in mice with established obesity (induced by 12 weeks of HF diet (60% fat as kcal)) compared to obese mice consuming a HF or low-fat (LF) weight loss control diet. Obese C57BL/6 male mice remained consuming HF for eight weeks or were randomly switched from HF to an isocaloric HF with 15.7% cooked navy bean powder diet (HFàHFB) or LF (11% fat as kcal; HFàLF) ( = 12/group). HFàHFB improved the obese phenotype, including (i) fecal microbiome (increased , , and short-chain fatty acid levels), (ii) intestinal health (increased , , , , and expression), and (iii) reduced adipose tissue (AT) inflammatory proteins (NFκBp65, STAT3, IL-6, MCP-1, and MIP-1α), versus HF ( < 0.05). Conversely, HFàLF reduced body weight and circulating hormones (leptin, resistin, and PAI-1) versus HF and HFàHFB ( < 0.05); however, AT inflammation and intestinal health markers were not improved to the same degree as HFàHFB ( < 0.05). Despite remaining on a HF obesogenic diet, introducing beans in established obesity improved the obese phenotype (intestinal health and adipose inflammation) more substantially than weight loss alone.
烹饪后的普通豆类（）可改善瘦鼠的肠道健康，并在肥胖发展过程中同时消耗时减轻肠道菌群失调和炎症。我们确定了高脂肪（HF）豆类补充饮食在肥胖小鼠（通过 12 周的 HF 饮食（60％的脂肪作为卡路里）诱导）中的作用，与消耗 HF 或低脂（LF）减肥对照饮食的肥胖小鼠相比。肥胖的 C57BL/6 雄性小鼠继续消耗 HF 八周，或随机从 HF 切换到等热量的 HF 与 15.7％烹饪海军豆粉饮食（HFàHFB）或 LF（11％的脂肪作为卡路里; HFàLF）（= 12/组）。HFàHFB 改善了肥胖表型，包括（i）粪便微生物组（增加了，，和短链脂肪酸水平），（ii）肠道健康（增加了，，，，和表达），和（iii）减少脂肪组织（AT）炎症蛋白（NFκBp65、STAT3、IL-6、MCP-1 和 MIP-1α），与 HF 相比（<0.05）。相反，HFàLF 与 HF 和 HFàHFB 相比，降低了体重和循环激素（瘦素、抵抗素和 PAI-1）（<0.05）; 然而，AT 炎症和肠道健康标志物的改善程度不如 HFàHFB（<0.05）。尽管仍然处于致肥胖的 HF 饮食中，但在肥胖中引入豆类可大大改善肥胖表型（肠道健康和脂肪炎症），比单独减肥效果更显著。
