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岩藻黄醇，一种源自藻类的酚类化合物，可抑制紫外线B诱导的人真皮成纤维细胞皮肤损伤及其潜在机制。

Dieckol, an Algae-Derived Phenolic Compound, Suppresses UVB-Induced Skin Damage in Human Dermal Fibroblasts and Its Underlying Mechanisms.

作者信息

Wang Lei, Je Jun-Geon, Yang Hye-Won, Jeon You-Jin, Lee Seungheon

机构信息

College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.

Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea.

出版信息

Antioxidants (Basel). 2021 Feb 26;10(3):352. doi: 10.3390/antiox10030352.

DOI:10.3390/antiox10030352
PMID:33652913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7996756/
Abstract

Ultraviolet (UV) irradiation is considered to be the primary environmental factor that causes skin damage. In the present study, we investigated the protective effect of dieckol (DK), a compound isolated from the brown seaweed , against UVB-induced skin damage in human dermal fibroblasts (HDF cells). The results indicated that DK effectively inhibited the activity of collagenase. DK remarkably reduced the intracellular reactive oxygen species level and improved the viability of UVB-irradiated HDF cells. Besides, DK significantly and dose-dependently improved collagen synthesis and inhibited intracellular collagenase activity in UVB-irradiated HDF cells. In addition, DK markedly reduced the expression of proinflammatory cytokines and matrix metalloproteinases. Further analyses revealed that these processes were mediated through the regulation of nuclear factor kappa B, activator protein 1, and mitogen-activated protein kinase signaling pathways in the UVB-irradiated HDF cells. In conclusion, these results indicate that DK possesses strong in vitro photoprotective effects and therefore has the potential to be used as an ingredient in the cosmeceutical industry.

摘要

紫外线（UV）照射被认为是导致皮肤损伤的主要环境因素。在本研究中，我们研究了从褐藻中分离出的化合物二eckol（DK）对人皮肤成纤维细胞（HDF细胞）中UVB诱导的皮肤损伤的保护作用。结果表明，DK有效抑制了胶原酶的活性。DK显著降低了细胞内活性氧水平，提高了UVB照射的HDF细胞的活力。此外，DK显著且剂量依赖性地改善了UVB照射的HDF细胞中的胶原蛋白合成并抑制了细胞内胶原酶活性。此外，DK显著降低了促炎细胞因子和基质金属蛋白酶的表达。进一步分析表明，这些过程是通过调节UVB照射的HDF细胞中的核因子κB、活化蛋白1和丝裂原活化蛋白激酶信号通路介导的。总之，这些结果表明DK具有强大的体外光保护作用，因此有潜力用作药妆行业的成分。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/6f1d5077b1d0/antioxidants-10-00352-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/bf879bf9bb8f/antioxidants-10-00352-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/ded89d035400/antioxidants-10-00352-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/de2d0f5c50e5/antioxidants-10-00352-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/cdb92c2bbc83/antioxidants-10-00352-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/a08a4061077b/antioxidants-10-00352-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/79f16f00fb58/antioxidants-10-00352-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/6f1d5077b1d0/antioxidants-10-00352-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/bf879bf9bb8f/antioxidants-10-00352-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/ded89d035400/antioxidants-10-00352-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/de2d0f5c50e5/antioxidants-10-00352-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/cdb92c2bbc83/antioxidants-10-00352-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/a08a4061077b/antioxidants-10-00352-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/79f16f00fb58/antioxidants-10-00352-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a803/7996756/6f1d5077b1d0/antioxidants-10-00352-g007.jpg

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