CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal; Department of Chemical Engineering, University of Porto, Porto, Portugal.
CBQF - Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Porto, Portugal.
Int J Biol Macromol. 2020 Sep 15;159:1177-1185. doi: 10.1016/j.ijbiomac.2020.05.077. Epub 2020 May 19.
Chitosan is a natural polysaccharide widely used in biomedicine, for instance for wound dressing. Hydroxyapatite is a very bioactive calcium phosphate which, if modified with an appropriate element (iron Fe), can also have UV-absorbing properties. In this work, we report the study of films of chitosan incorporated with iron-modified hydroxyapatite of natural origin (from cod fish bones); this combination led to an innovative chitosan-based material with excellent and advanced functional properties. The films showed very high UV absorption (Ultraviolet Protection Factor (UPF) value higher than 50). This is the first time that a chitosan-based material has shown such high UV protection properties. The films also showed to be non-cytotoxic, and possessed antimicrobial activity towards both Gram-positive and negative strains. Their mechanical properties, optimised with an experimental design approach, confirmed their potential use as multifunctional wound dressing, capable of reducing bacterial infections and, at the same time, protecting from UV light.
壳聚糖是一种天然多糖，广泛应用于生物医药领域，例如用于伤口敷料。羟基磷灰石是一种非常具有生物活性的磷酸钙，如果用适当的元素（铁 Fe）进行修饰，也可以具有紫外线吸收特性。在这项工作中，我们报告了研究壳聚糖与天然来源（来自鳕鱼骨）的铁修饰羟基磷灰石的复合薄膜；这种组合导致了一种具有优异和先进功能特性的新型壳聚糖基材料。该薄膜表现出非常高的紫外线吸收（紫外线防护因子（UPF）值高于 50）。这是第一次展示出具有如此高的紫外线保护性能的壳聚糖基材料。该薄膜还显示出非细胞毒性，并对革兰氏阳性和阴性菌株均具有抗菌活性。通过实验设计方法优化了它们的机械性能，证实了它们作为多功能伤口敷料的潜在用途，能够减少细菌感染，同时保护免受紫外线的伤害。
