Center for Gynecologic Cancer, National Cancer Center, 323 Ilsan-ro, Goyang 10408, Korea.
College of Nursing, Woosuk University, Wanju 55338, Korea.
Int J Environ Res Public Health. 2021 Feb 26;18(5):2312. doi: 10.3390/ijerph18052312.
This study assessed the knowledge and attitude of patients with ovarian cancer (OC) toward OC and next generation sequencing (NGS). The data, including characteristics of patients, their knowledge about OC and their knowledge and attitude of NGS, were collected from June to October 2018. Of the 103 participants, 70.9% ( = 73) had cancer within the second-degree relatives, and 18.4% ( = 19) had pathogenic mutations. The percentage of right answer for the knowledge about OC and NGS was 64.7% (11/17) and 50% (6/12), respectively. The median number of patients who had positive expectations for the genetic test was 34 (range, 22-44). Based on a first-degree familial history, patients had a different degree of knowledge about OC (11 vs. 8.5, = 0.026) and NGS (6.5 vs. 5, = 0.011), but patients with a pathogenic mutation did not have a different degree of knowledge about OC and NGS panel testing. High-income families had a more positive attitude towards the genetic test than low-income families ( = 0.005). Women with OC do not have enough knowledge about OC (11/17, 64.7%) and NGS (6/12, 50%) but they showed a positive attitude toward the NGS test. These women need OC and NGS educational intervention.
本研究评估了卵巢癌（OC）患者对 OC 和下一代测序（NGS）的知识和态度。这些数据包括患者的特征、他们对 OC 的了解以及他们对 NGS 的了解和态度，是在 2018 年 6 月至 10 月间收集的。在 103 名参与者中，70.9%（=73）的患者有二级亲属癌症史，18.4%（=19）有致病性突变。OC 和 NGS 知识的正确答案比例分别为 64.7%（11/17）和 50%（6/12）。对基因检测有积极期望的患者中位数为 34 人（范围 22-44）。根据一级家族病史，患者对 OC（11 与 8.5， = 0.026）和 NGS（6.5 与 5， = 0.011）的了解程度不同，但有致病性突变的患者对 OC 和 NGS 面板检测的了解程度没有差异。高收入家庭比低收入家庭对基因检测的态度更为积极（ = 0.005）。OC 患者对 OC（11/17，64.7%）和 NGS（6/12，50%）的了解不足，但他们对 NGS 检测表现出积极态度。这些女性需要 OC 和 NGS 的教育干预。
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