J Biomed Nanotechnol. 2021 Jan 1;17(1):53-63. doi: 10.1166/jbn.2021.3018.
Compared with western medicine, traditional Chinese medicine can better regulate the internal environment and inhibit liver cancer recurrence and metastasis. Bushen Jianpi Recipe (BSJPR) is a traditional Chinese medicine for tonifying the kidney and invigorating the spleen. It has also been used to treat tumors and other related diseases. Here we explore the efficacy of BSJPR inhibition of hepatocellular carcinoma (HCC) in vivo and in vitro . We hypothesize that BSJPR reduces intrahepatic cholestasis and inflammation and increases expression of the bile acid receptor and downstream targets. This study aims to test this hypothesis and determine whether the inhibitory effect of BSJPR on liver cancer recurrence and metastasis is related to bile acid metabolism. We also observed changes in immune cell expression, suggesting that regulation of the immune microenvironment could inhibit the recurrence and metastasis of HCC. These findings provide a basis for the treatment of HCC and new ideas for follow-up studies of BSJPR.
与西药相比，中药能更好地调节内环境，抑制肝癌的复发和转移。补肾健脾方（BSJPR）是一种补肾健脾的中药，也被用于治疗肿瘤等相关疾病。在这里，我们探讨了 BSJPR 对体内和体外肝癌的抑制作用。我们假设 BSJPR 可减少肝内胆汁淤积和炎症，并增加胆汁酸受体和下游靶标的表达。本研究旨在检验这一假设，并确定 BSJPR 对肝癌复发和转移的抑制作用是否与胆汁酸代谢有关。我们还观察到免疫细胞表达的变化，提示免疫微环境的调节可能抑制 HCC 的复发和转移。这些发现为 HCC 的治疗提供了依据，并为 BSJPR 的后续研究提供了新的思路。
