Medical College of Wisconsin, Milwaukee, Wisconsin
Medical College of Wisconsin, Milwaukee, Wisconsin.
Hosp Pediatr. 2021 Apr;11(4):350-357. doi: 10.1542/hpeds.2020-003665. Epub 2021 Mar 2.
The Modified Finnegan Neonatal Abstinence Scoring System (M-FNASS) and the newer Eat, Sleep, and Console (ESC) model guide the clinical management of neonatal opioid withdrawal syndrome (NOWS). In this study, we evaluate how the M-FNASS and ESC model directly compare in inpatient practice. We hypothesized that ESC scores would correlate with M-FNASS scores, whereas ESC management would reduce health care use for infants with NOWS.
In this retrospective cohort study, we compared management of infants with NOWS admitted to nursery settings. Epoch 1 was managed by using an M-FNASS algorithm. Epoch 2 was scored simultaneously with the M-FNASS and ESC model and managed by using the ESC approach. In the statistical analysis, we compared M-FNASS and ESC scores and outcomes between epochs.
A total of 158 infants provided 2101 scoring instances for analysis. Demographic characteristics were similar between epochs. ESC scores significantly correlated with overall M-FNASS scores and specific M-FNASS domains. Receiver operating characteristic (ROC) curve analysis revealed that an ESC score containing at least 1 "no" was best predicted by an M-FNASS cutoff value of 7.5 (sensitivity 0.84; specificity 0.70; area under the curve = 0.842). Length of stay (median 9.5 vs 5 days; = .0002) and initiation (53% vs. 33%; = .018) and duration of pharmacologic treatment (median 11 vs 7 days; = .0042), as well as length of stay for infants who were pharmacologically treated (median 15 vs 10 days; = .0002), were significantly reduced with ESC-based management after adjustment for covariates.
The ESC approach meaningfully correlates with the M-FNASS to detect NOWS. Management with the ESC approach continues to be associated with reduced health care use when compared with an M-FNASS approach, implying that the ESC approach may facilitate higher-value inpatient care.
改良芬纳根新生儿戒断评分系统(M-FNASS)和更新的进食、睡眠和安抚(ESC)模型指导新生儿阿片类戒断综合征(NOWS)的临床管理。在这项研究中,我们评估了 M-FNASS 和 ESC 模型在住院患者中的直接比较。我们假设 ESC 评分与 M-FNASS 评分相关,而 ESC 管理将减少 NOWS 婴儿的医疗保健使用。
在这项回顾性队列研究中,我们比较了在托儿所环境中接受 NOWS 治疗的婴儿的管理情况。第 1 个时期采用 M-FNASS 算法进行管理。第 2 个时期同时采用 M-FNASS 和 ESC 模型进行评分,并采用 ESC 方法进行管理。在统计分析中,我们比较了两个时期的 M-FNASS 和 ESC 评分和结果。
共有 158 名婴儿提供了 2101 个评分实例进行分析。两个时期的人口统计学特征相似。ESC 评分与整体 M-FNASS 评分和特定 M-FNASS 领域显著相关。接受者操作特征(ROC)曲线分析显示,包含至少 1 个“否”的 ESC 评分最佳预测值为 M-FNASS 截断值为 7.5(敏感性 0.84;特异性 0.70;曲线下面积=0.842)。与 ESC 管理相比,住院时间(中位数 9.5 天与 5 天;=0.0002)和药物治疗的开始(53%与 33%;=0.018)和持续时间(中位数 11 天与 7 天;=0.0042),以及接受药物治疗的婴儿的住院时间(中位数 15 天与 10 天;=0.0002)显著减少。
ESC 方法与 M-FNASS 有意义地相关,可用于检测 NOWS。与 M-FNASS 方法相比,ESC 方法的管理继续与减少医疗保健使用相关,这意味着 ESC 方法可能有助于提供更高价值的住院护理。