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一种评估新生儿戒断综合征婴儿的新方法。

A Novel Approach to Assessing Infants With Neonatal Abstinence Syndrome.

作者信息

Grossman Matthew R, Lipshaw Matthew J, Osborn Rachel R, Berkwitt Adam K

机构信息

Department of Pediatrics, School of Medicine, Yale University, New Haven, Connecticut; and

Department of Pediatrics, School of Medicine, Yale University, New Haven, Connecticut; and.

出版信息

Hosp Pediatr. 2018 Jan;8(1):1-6. doi: 10.1542/hpeds.2017-0128.

Abstract

OBJECTIVES

Neonatal abstinence syndrome (NAS) is a growing problem and poses a significant burden on the health care system. The traditional Finnegan Neonatal Abstinence Scoring System (FNASS) assessment approach may lead to unnecessary opioid treatment of infants with NAS. We developed a novel assessment approach and describe its effect on the management of infants with NAS.

METHODS

We retrospectively compared treatment decisions of 50 consecutive opioid-exposed infants managed on the inpatient unit at the Yale New Haven Children's Hospital. All infants had FNASS scores recorded every 2 to 6 hours but were managed by using the Eat, Sleep, Console (ESC) assessment approach. Actual treatment decisions made by using the ESC approach were compared with predicted treatment decisions based on recorded FNASS scores. The primary outcome was postnatal treatment with morphine.

RESULTS

By using the ESC approach, 6 infants (12%) were treated with morphine compared with 31 infants (62%) predicted to be treated with morphine by using the FNASS approach ( < .001). The ESC approach started or increased morphine on 8 days (2.7%) compared with 76 days (25.7%) predicted by using the FNASS approach ( < .001). There were no readmissions or adverse events reported.

CONCLUSIONS

Infants managed by using the ESC approach were treated with morphine significantly less frequently than they would have been by using the FNASS approach. The ESC approach is an effective method for the management of infants with NAS that limits pharmacologic treatment and may lead to substantial reductions in length of stay.

摘要

目的

新生儿戒断综合征(NAS)是一个日益严重的问题,给医疗保健系统带来了巨大负担。传统的芬尼根新生儿戒断评分系统(FNASS)评估方法可能会导致对NAS婴儿进行不必要的阿片类药物治疗。我们开发了一种新的评估方法,并描述了其对NAS婴儿管理的影响。

方法

我们回顾性比较了耶鲁纽黑文儿童医院住院部连续管理的50例阿片类药物暴露婴儿的治疗决策。所有婴儿每2至6小时记录一次FNASS评分,但采用进食、睡眠、安抚(ESC)评估方法进行管理。将使用ESC方法做出的实际治疗决策与基于记录的FNASS评分预测的治疗决策进行比较。主要结局是出生后使用吗啡治疗。

结果

采用ESC方法,6例婴儿(12%)接受了吗啡治疗,而采用FNASS方法预测接受吗啡治疗的婴儿为31例(62%)(P<0.001)。ESC方法在8天(2.7%)开始或增加了吗啡治疗,而采用FNASS方法预测为76天(25.7%)(P<0.001)。没有再入院或不良事件报告。

结论

采用ESC方法管理的婴儿接受吗啡治疗的频率明显低于采用FNASS方法时的频率。ESC方法是管理NAS婴儿的一种有效方法,可限制药物治疗,并可能大幅缩短住院时间。

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