前白蛋白与风湿性肌肉骨骼疾病中的 C 反应蛋白相关。

Prealbumin Correlates with C-reactive Protein in Rheumatic Musculoskeletal Diseases.

机构信息

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Department of Clinical Laboratory, The First Hospital of Jilin University, Jilin, China.

出版信息

Ann Clin Lab Sci. 2021 Jan;51(1):82-89.

PMID:33653784

Abstract

OBJECTIVE

Prealbumin is a blood component tested for nutrition monitoring, which could be affected during inflammation. This study aimed to investigate the relationships between prealbumin and C-reactive protein (CRP) in inflammatory rheumatic musculoskeletal diseases (RMDs), including Takayasu arteritis, antineutrophil cytoplasmic antibody-associated vasculitis, systemic lupus erythematosus, Behcet's disease and polymyositis/dermatomyositis.

METHODS

A total of 52 healthy controls and 508 RMD patients were included. We collected 3714 clinical and laboratory records from June 2011 to August 2019, and the longest follow-up period was eleven years. The associations between prealbumin and CRP, the globulin gap, the albumin-to-globulin ratio, and IgG were evaluated.

RESULTS

Prealbumin had a high correlation coefficient (r=-0.497, <0.001), consistent changes over time with CRP, and a high area under the curve [AUC=0.777 (95% CI 0.76-0.795)] for CRP. The statistical relationship between the prealbumin and CRP was not affected by sex, ethnicity or age. Among RMDs, prealbumin showed the strongest correlation with CRP in Takayasu arteritis (r=0.607, <0.001). In addition, a moderate relationship was observed between prealbumin and IgG, the globulin gap and the albumin-to-globulin ratio.

CONCLUSION

Prealbumin is closely related to CRP in Chinese patients with five chronic inflammatory RMDs, which may be due to the influence of chronic inflammation during the course of disease.

摘要

目的

前白蛋白是一种用于营养监测的血液成分，其水平可能会在炎症期间受到影响。本研究旨在探讨五种慢性炎症性风湿性肌肉骨骼疾病（RMDs）包括 Takayasu 动脉炎、抗中性粒细胞胞质抗体相关性血管炎、系统性红斑狼疮、贝赫切特病和多发性肌炎/皮肌炎患者的前白蛋白与 C 反应蛋白（CRP）之间的关系。

方法

共纳入 52 名健康对照者和 508 名 RMD 患者。我们收集了 2011 年 6 月至 2019 年 8 月的 3714 份临床和实验室记录，最长随访时间为十一年。评估了前白蛋白与 CRP、球蛋白差值、白蛋白/球蛋白比值和 IgG 的关系。

结果

前白蛋白与 CRP 具有高度相关系数（r=-0.497，<0.001），与 CRP 呈一致的时间变化趋势，且对 CRP 的曲线下面积（AUC=0.777（95%CI 0.76-0.795））较高。前白蛋白与 CRP 之间的统计学关系不受性别、种族或年龄的影响。在 RMDs 中，前白蛋白与 CRP 的相关性最强，在 Takayasu 动脉炎中（r=0.607，<0.001）。此外，前白蛋白与 IgG、球蛋白差值和白蛋白/球蛋白比值之间也存在中度关系。