原发性干燥综合征患者的血清转甲状腺素蛋白水平与疾病活动度
Serum transthyretin levels and disease activity in patients with primary Sjögren's syndrome.
作者信息
Peng You-Fan, Lu Fei-Yan, Deng Yi-Bin
机构信息
Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
Clinical Pathological Diagnosis and Research Centre, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China.
出版信息
Ther Adv Musculoskelet Dis. 2024 Oct 16;16:1759720X241283528. doi: 10.1177/1759720X241283528. eCollection 2024.
BACKGROUND
A strong association has been demonstrated between serum transthyretin (TTR) levels and autoimmune diseases. However, there is limited information regarding the role of serum TTR in patients with primary Sjögren's syndrome (pSS).
OBJECTIVES
This study was designed to explore the association between serum TTR and disease activity in patients with pSS.
DESIGN
This study was a retrospective observational study.
METHODS
This study included 84 patients with pSS and 135 age- and sex-matched healthy controls retrospectively, and collected data were analyzed. The European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease Activity Index (ESSDAI) and Clinical ESSDAI (ClinESSDAI) scores were used to assess the disease activity in patients with pSS.
RESULTS
Serum TTR levels were significantly lower in patients with pSS than those in healthy controls (181.9 ± 69.2 vs 241.8 ± 48.9 mg/L, < 0.001). Serum TTR levels were significantly and negatively correlated with ESSDAI ( = -0.385, < 0.001) and ClinESSDAI ( = -0.340, = 0.002) scores in patients with pSS, respectively. Multivariable linear regression analysis showed that serum TTR was significantly associated with ESSDAI (Beta = -0.248, = 0.017) and ClinESSDAI (Beta = -0.215, = 0.036) scores in patients with pSS, respectively.
CONCLUSION
Serum TTR is a potential marker for assessing disease activity in patients with pSS, which may contribute to the clinical management of pSS.
背景
血清甲状腺素运载蛋白（TTR）水平与自身免疫性疾病之间已证实存在密切关联。然而，关于血清TTR在原发性干燥综合征（pSS）患者中的作用，相关信息有限。
目的
本研究旨在探讨血清TTR与pSS患者疾病活动度之间的关联。
设计
本研究为回顾性观察性研究。
方法
本研究回顾性纳入了84例pSS患者和135例年龄及性别匹配的健康对照者，并对收集的数据进行分析。采用欧洲抗风湿病联盟（EULAR）干燥综合征疾病活动指数（ESSDAI）和临床ESSDAI（ClinESSDAI）评分来评估pSS患者的疾病活动度。
结果
pSS患者的血清TTR水平显著低于健康对照者（181.9±69.2 vs 241.8±48.9 mg/L，P<0.001）。pSS患者的血清TTR水平分别与ESSDAI（r=-0.385，P<0.001）和ClinESSDAI（r=-0.340，P=0.002）评分显著负相关。多变量线性回归分析显示，血清TTR分别与pSS患者的ESSDAI（β=-0.248，P=0.017）和ClinESSDAI（β=-0.215，P=0.036）评分显著相关。
结论
血清TTR是评估pSS患者疾病活动度的潜在标志物，可能有助于pSS的临床管理。
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