免疫检查点抑制剂诱导的免疫毒性的核心。

At the Heart of Immune Checkpoint Inhibitor-Induced Immune Toxicity.

机构信息

Sean N. Parker Autoimmune Research Laboratory and Diabetes Center, University of California, San Francisco, San Francisco, California.

QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia.

出版信息

Cancer Discov. 2021 Mar;11(3):537-539. doi: 10.1158/2159-8290.CD-21-0091.

DOI:10.1158/2159-8290.CD-21-0091

PMID:33653918

Abstract

Wei and colleagues showcase a genetic mouse model of immune-mediated myocarditis that shares homology with immune checkpoint inhibitor (CPI)-induced myocarditis in patients with cancer. They demonstrate that abatacept (CTLA4-Ig) limits cardiac toxicity in the mouse model and, thus, may ameliorate the CPI-induced myocarditis in patients with cancer while potentially maintaining antitumor activity..

摘要

魏及其同事展示了一种免疫介导性心肌炎的遗传小鼠模型，该模型与癌症患者免疫检查点抑制剂（CPI）诱导的心肌炎具有同源性。他们表明阿巴西普（CTLA4-Ig）可限制小鼠模型中的心脏毒性，因此可能在维持抗肿瘤活性的同时改善癌症患者的 CPI 诱导性心肌炎。