From the Department of Dermatology, University of Colorado, Aurora.
Department of Medicine, Tulane University, New Orleans, LA.
Dermatitis. 2022;33(4):277-281. doi: 10.1097/DER.0000000000000722.
Chronic inflammatory skin disorders, such as atopic dermatitis, have significant disease burden worldwide. Although efficacious, the adverse effect profile of topical corticosteroids limits long-term use. As an alternative, cannabinoids have been shown to have anti-inflammatory therapeutic effects.
The aim of this study was to assess the effects of a topical cannabinoid product using dermatitis mouse model.
Thirty-five mice were randomized into treatment groups. 12- O -tetradecanoylphorbol-13-acetate was used as an irritant on 1 ear with the contralateral ear serving as a control. Ear edema was calipered. The test product containing 0.9% cannabidiol and palmitoylethanolamide was compared with a potent topical corticosteroid.
Treatment with topical cannabinoid formulation reduced ear edema by 51.27% at 24 hours' and 65.69% at 48 hours' postapplication. Alternatively, mometasone reduced ear edema by 89.82% at 24 hours and 98.25% at 48 hours. Natural reduction (control) in ear edema was 26.32% at 24 hours and 44.21% at 48 hours. Both test groups resulted in significantly decreased edema when compared with baseline ( P < 0.05), as well as compared with the negative control group ( P < 0.05).
Significant reduction in ear edema, a marker for localized cutaneous inflammation, could be attributed to anti-inflammatory properties of cannabinoids. Although effects were less robust than topical corticosteroid use, cannabinoid formulations have therapeutic promise for dermatitis.
慢性炎症性皮肤疾病，如特应性皮炎，在全球范围内具有显著的疾病负担。尽管局部皮质类固醇疗效确切，但不良反应限制了其长期使用。作为替代治疗，大麻素具有抗炎治疗作用。
本研究旨在通过皮炎小鼠模型评估局部大麻素产品的疗效。
35 只小鼠随机分为治疗组。用 12-O-十四烷酰佛波醇-13-醋酸酯作为刺激性物质作用于一侧耳，对侧耳作为对照。用卡尺测量耳肿胀程度。与强效局部皮质类固醇相比，测试产品含有 0.9%的大麻二酚和棕榈酸乙醇酰胺。
局部大麻素制剂在应用后 24 小时和 48 小时分别可使耳肿胀减少 51.27%和 65.69%。相比之下，莫米松在 24 小时和 48 小时分别可使耳肿胀减少 89.82%和 98.25%。自然减少（对照）在 24 小时和 48 小时分别为 26.32%和 44.21%。与基线相比（P<0.05），两组治疗组均显著降低了耳肿胀，与阴性对照组相比（P<0.05）也显著降低了耳肿胀。
耳肿胀（局部皮肤炎症的标志物）显著减少可能归因于大麻素的抗炎特性。虽然其效果不如局部皮质类固醇，但大麻素制剂对皮炎具有治疗潜力。
