Ligand-binding properties of albumin Parklands: Asp365----His.

An albumin variant, isolated from the plasma of a patient with bisalbuminemia, was compared with albumin A from the same patient for binding of long-chain fatty acids and bilirubin. No differences in binding of [14C]palmitate, cis-parinaric acid or bilirubin could be detected for the variant form. These results suggest that the region adjacent to residue 365 is unlikely to be part of a major binding site for any of these ligands.