Kasai Emmanuel Tebandite, Opara Jean Pierre Alworong A, Agasa Salomon Batina, Gulbis Béatrice, Uvoya Naura Apio, Nguma Jean Didier Bosenge, Maloba Philippe Kasongo, Hubert Philippe, Etienne Anne-Marie, Djang Eing A Roland Marini
Département de Pédiatrie, Faculté de Médecine et de Pharmacie, Université de Kisangani, Kisangani, République Démocratique du Congo.
Département de Médecine Interne, Faculté de Médecine et de Pharmacie, Université de Kisangani, Kisangani, République Démocratique du Congo.
Pan Afr Med J. 2020 Dec 2;37:299. doi: 10.11604/pamj.2020.37.299.26654. eCollection 2020.
the implementation of neonatal screening to identify infants with sickle cell disease during the COVID-19 pandemic is a major challenge in the Democratic Republic of the Congo (DRC). The purpose of this study is to determine whether socio-economic factors are associated with acceptability of newborn screening to identify infants with sickle cell disease during the COVID-19 pandemic in Kisangani, DRC.
we conducted an observational study of mothers sensitized to neonatal screening to detect sickle cell disease in their newborns with hemotypeSC (HT401RUO-USA). The study was carried out at the maternity wards in Kisangani from March 21 to June 30 2020. Collected data were parity, educational level, age, socio-economic level, occupation, awareness and the reason for the denial of screening.
out of 55.5% (273/492) of sensitized mothers, 107 (39.19%) accepted and 166 (60.80%) refused neonatal screening to detect sickle cell disease in their newborn. The reasons for refusal were lack of information (67.5%; 95% CI [59.8-74.5]), lack of money due to confinement (66.3%; 95% CI [58.5-73.4]), blood test to develop a vaccine for protection against COVID-19 (63.2%; 95% CI = [55.4-70.6]). Factors associated with the acceptability of screening were age > 35 years (p = 0.0009; ORa = 3.04; 95% CI = 1.57-5.87) and low socio-economic level (p = 0.0016; ORa = 2.29; 95% CI = 1.37-3.85).
the acceptability of neonatal screening to detect sickle cell disease during COVID-19 is low in Kisangani. The government should identify effective communication channels to promote health care initiatives.
在刚果民主共和国（DRC），在新冠疫情期间实施新生儿筛查以识别镰状细胞病婴儿是一项重大挑战。本研究的目的是确定在刚果民主共和国基桑加尼的新冠疫情期间，社会经济因素是否与新生儿筛查以识别镰状细胞病婴儿的可接受性相关。
我们对已了解新生儿筛查以检测其新生儿镰状细胞病（血型SC，HT401RUO - 美国）的母亲进行了一项观察性研究。该研究于2020年3月21日至6月30日在基桑加尼的产科病房进行。收集的数据包括产次、教育水平、年龄、社会经济水平、职业、认知情况以及拒绝筛查的原因。
在55.5%（273/492）已了解情况的母亲中，107名（39.19%）接受了对其新生儿进行镰状细胞病检测的新生儿筛查，166名（60.80%）拒绝了。拒绝的原因包括信息不足（67.5%；95%置信区间[59.8 - 74.5]）、因隔离导致资金短缺（66.3%；95%置信区间[58.5 - 73.4]）、用于研发新冠疫苗的血液检测（63.2%；95%置信区间 = [55.4 - 70.6]）。与筛查可接受性相关的因素是年龄>35岁（p = 0.0009；优势比a = 3.04；95%置信区间 = 1.57 - 5.87）和社会经济水平低（p = 0.0016；优势比a = 2.29；95%置信区间 = 1.37 - 3.85）。
在基桑加尼，新冠疫情期间新生儿筛查以检测镰状细胞病的可接受性较低。政府应确定有效的沟通渠道以促进医疗保健举措。
