Faculty of Medicine and Pharmacy, University of Kisangani, Kisangani, Democratic Republic of the Congo.
Faculty of Medicine, University of Liège, Liège, Belgium.
Hematology. 2021 Dec;26(1):199-205. doi: 10.1080/16078454.2021.1880752.
The Democratic Republic of the Congo (DRC) is the third most affected country worldwide by sickle cell disease (SCD). However, this disease is still orphaned in the country; large-scale control actions are rare, and little is known about its management.
To assess current practices in the management of SCD in Kisangani, DRC.
This cross-sectional study was conducted in six health facilities in Kisangani. It involved 198 presumed sickle cell patients attending the above health facilities. The study focused on the sociodemographic and clinical data of the participants, obtained through a clinical examination and their medical records. Diagnostic confirmation of SCD was made by high-performance liquid chromatography coupled to mass spectrometry. Data were analyzed using SPSS 20.0.
The diagnosis of SCD was confirmed in 194 (98.0%; 95% CI: 94.9-99.2) participants, while it was not confirmed in 4 (2.0%; 95% CI: 0.8-5.1) participants. The diagnosis was mainly made by the Emmel test (42.9%). 45.8% of participants had previously been transfused with the blood of their parents. Folic acid was taken by 48.5% of participants and the previous intake of hydroxyurea was reported in 5.1% of participants. The participants vaccinated against were 13.6% and against type b 28.3%. Penicillin prophylaxis was received by only 1.5% and malaria prophylaxis by 11.6% of participants.
Standard-care practices for SCD patients in Kisangani are insufficient. The Congolese government should regard this disease as a health priority and consider actions to improve its management.
刚果民主共和国（DRC）是全球受镰状细胞病（SCD）影响的第三大国家。然而，这种疾病在该国仍未得到重视；大规模的控制行动很少，对其管理知之甚少。
评估刚果民主共和国金沙萨 SCD 的当前管理实践。
这是一项在金沙萨的六家卫生机构中进行的横断面研究。它涉及了 198 名疑似镰状细胞病患者。研究重点是参与者的社会人口学和临床数据，这些数据是通过临床检查和他们的医疗记录获得的。SCD 的诊断通过高效液相色谱-质谱联用进行。使用 SPSS 20.0 对数据进行分析。
194 名（98.0%；95%CI：94.9-99.2）参与者的 SCD 诊断得到了确认，而 4 名（2.0%；95%CI：0.8-5.1）参与者的诊断未得到确认。诊断主要通过埃米尔试验（42.9%）进行。45.8%的参与者曾接受过父母的输血。48.5%的参与者服用过叶酸，5.1%的参与者曾服用过羟基脲。接种 的参与者占 13.6%，接种 型 b 的参与者占 28.3%。只有 1.5%的参与者接受过青霉素预防，11.6%的参与者接受过疟疾预防。
金沙萨 SCD 患者的标准护理实践不足。刚果政府应将这种疾病视为卫生重点，并考虑采取行动改善其管理。
