Onodera Koki, Kurisu Kota, Takebayashi Seiji, Sakurai Juro, Kobayashi Tohru, Kobayashi Rina, Goto Shuho, Takizawa Katsumi
Department of Neurosurgery, Asahikawa Red Cross Hospital, Asahikawa, Hokkaido, Japan.
Surg Neurol Int. 2021 Feb 17;12:55. doi: 10.25259/SNI_693_2020. eCollection 2021.
Intracranial and central nervous system's involvement with multiple myeloma (MM) is a clinically rare manifestation. Furthermore, the development of intracranial plasmacytoma without bone involvement is much rarer. Herein, we report the case of massive intracerebral hemorrhage form intracranial plasmacytoma that arose from the dura mater without bone involvement.
A 71-year-old woman, who had been diagnosed as MM and treated 2 years prior, developed sudden lethal intracerebral hemorrhage from the intracranial plasmacytoma. Massive hemorrhage was observed after a rapid tumor growth in the middle fossa. Immediate hematoma evacuation and tumor resection allowed the patient to avoid severe neurological deficits and lethal conditions.
A close follow-up by neuroimaging studies is essential in cases of intracranial plasmacytoma in MM patients and early intervention with surgical resection or radiotherapy should be considered.
颅内及中枢神经系统受累于多发性骨髓瘤（MM）是一种临床罕见的表现。此外，无骨受累的颅内浆细胞瘤的发生更为罕见。在此，我们报告一例起源于硬脑膜且无骨受累的颅内浆细胞瘤导致大量脑出血的病例。
一名71岁女性，2年前被诊断为MM并接受治疗，因颅内浆细胞瘤突发致死性脑出血。中颅窝肿瘤快速生长后出现大量出血。立即进行血肿清除和肿瘤切除使患者避免了严重的神经功能缺损和致命情况。
对于MM患者的颅内浆细胞瘤病例，通过神经影像学检查进行密切随访至关重要，应考虑早期进行手术切除或放疗干预。
