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环状二鸟苷单磷酸（CDG）佐剂蛋白亚单位疫苗对黏膜和全身疫苗反应的评估

Evaluation of Mucosal and Systemic Vaccine Responses by Cyclic di-GMP (CDG)-adjuvanted Protein Subunit Vaccines.

作者信息

Mansouri Samira, Jin Lei

机构信息

Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA.

出版信息

Bio Protoc. 2019 Apr 20;9(8):e3217. doi: 10.21769/BioProtoc.3217.

DOI:10.21769/BioProtoc.3217
PMID:33655008
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7854200/
Abstract

Intranasal administration of vaccine adjuvants directly deliver therapeutic agents to the lungs to induce potent lung mucosal immune responses. Cyclic di-GMP (CDG) is a promising mucosal vaccine adjuvant candidate capable of inducing protective immunity. This protocol describes an approach to induce and detect mucosal (lung) and systemic (blood and spleen) vaccine adjuvant responses of CDG. This protocol also includes the methods to detect both humoral and cellular immune responses of CDG adjuvant. Last, this protocol can be used to study other cyclic dinucleotides as mucosal vaccine adjuvants.

摘要

经鼻内给药的疫苗佐剂可将治疗剂直接递送至肺部，以诱导强大的肺黏膜免疫反应。环二鸟苷酸（CDG）是一种有前景的黏膜疫苗佐剂候选物，能够诱导保护性免疫。本方案描述了一种诱导和检测CDG的黏膜（肺）和全身（血液和脾脏）疫苗佐剂反应的方法。本方案还包括检测CDG佐剂的体液免疫和细胞免疫反应的方法。最后，本方案可用于研究其他环二核苷酸作为黏膜疫苗佐剂。

相似文献

[1]
Evaluation of Mucosal and Systemic Vaccine Responses by Cyclic di-GMP (CDG)-adjuvanted Protein Subunit Vaccines.

Bio Protoc. 2019-4-20

[2]
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Front Immunol. 2022

[3]
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[4]
Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice.

Vaccine. 2011-5-18

[5]
New MoDC-Targeting TNF Fusion Proteins Enhance Cyclic Di-GMP Vaccine Adjuvanticity in Middle-Aged and Aged Mice.

Front Immunol. 2020

[6]
A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung.

Vaccine. 2014-5-30

[7]
Immature lung TNFR2 conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo.

Mucosal Immunol. 2018-10-16

[8]
The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo.

Elife. 2015-4-21

[9]
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Vaccine. 2011-5-19

[10]
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引用本文的文献

[1]
Mixed lipopeptide-based mucosal vaccine elicits a long-term bone marrow memory response that is potentially cross-reactive against a broad-spectrum of coronaviruses in mice.

Front Immunol. 2025-7-28

[2]
Mucosal immunization with lipopeptides derived from conserved regions of SARS-CoV-2 antigens induce robust cellular and cross-variant humoral immune responses in mice.

Front Immunol. 2023

[3]
The Mucoadhesive Nanoparticle-Based Delivery System in the Development of Mucosal Vaccines.

Int J Nanomedicine. 2022

本文引用的文献

[1]
Immature lung TNFR2 conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo.

Mucosal Immunol. 2018-10-16

[2]
The mucosal adjuvant cyclic di-GMP enhances antigen uptake and selectively activates pinocytosis-efficient cells in vivo.

Elife. 2015-4-21

[3]
MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3'-5')-cyclic-di-guanosine-monophosphate in vivo.

J Immunol. 2013-12-4

[4]
Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice.

Vaccine. 2011-5-18

[5]
A host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP.

J Exp Med. 2009-8-31

[6]
3',5'-Cyclic diguanylic acid elicits mucosal immunity against bacterial infection.

Biochem Biophys Res Commun. 2009-9-25

[7]
The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant.

Clin Vaccine Immunol. 2007-8

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