Sagar H J, Cohen N J, Sullivan E V, Corkin S, Growdon J H
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Boston.
Brain. 1988 Feb;111 ( Pt 1):185-206. doi: 10.1093/brain/111.1.185.
Remote memory for public and personal events was evaluated in Alzheimer's disease (AD) and Parkinson's disease (PD), using a series of recall and recognition tests. Information related to content and date of past events was assessed separately. In recall of the content of personal and public events, both groups showed a gradient of deficit in which remote events were affected less than recent ones; the magnitude and temporal extent of the retrograde loss was related to severity of dementia. By contrast, gradient effects were not evident in the recall of date and were less marked in the recognition of content or date. In public and personal events tests, patients with PD showed a relative impairment in dating capacity, compared with their memory for the content of events, which was independent of dementia. These results suggest that dementia affects the recall of distant events less than recall of recent ones. Furthermore, the selective gradient effects in recall of content suggest that memory for date is served by cognitive processes independent of memory for event content. In PD, dating capacity is a sensitive measure of remote memory function that may be disrupted independently of dementia.
我们使用一系列回忆和识别测试，对阿尔茨海默病（AD）和帕金森病（PD）患者的公共及个人事件的远期记忆进行了评估。分别评估了与过去事件的内容和日期相关的信息。在回忆个人和公共事件的内容时，两组患者均呈现出缺陷梯度，即远期事件比近期事件受影响小；逆行性记忆丧失的程度和时间范围与痴呆严重程度相关。相比之下，在回忆日期时未发现梯度效应，在识别内容或日期时梯度效应也不明显。在公共和个人事件测试中，与事件内容记忆相比，PD患者在日期记忆能力方面表现出相对损伤，且该损伤与痴呆无关。这些结果表明，痴呆对远期事件回忆的影响小于对近期事件回忆的影响。此外，在回忆内容时的选择性梯度效应表明，日期记忆由独立于事件内容记忆的认知过程支持。在PD中，日期记忆能力是远期记忆功能的一个敏感指标，可能独立于痴呆而受到干扰。
