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帕金森病和阿尔茨海默病在标准行为测试中的不同认知特征。

Different cognitive profiles on standard behavioral tests in Parkinson's disease and Alzheimer's disease.

作者信息

Sullivan E V, Sagar H J, Gabrieli J D, Corkin S, Growdon J H

机构信息

Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology.

出版信息

J Clin Exp Neuropsychol. 1989 Dec;11(6):799-820. doi: 10.1080/01688638908400937.

DOI:10.1080/01688638908400937
PMID:2592525
Abstract

Patients with Parkinson's disease (PD) displayed a different pattern of cognitive deficit from patients with dementia resulting from Alzheimer's disease (AD). Specifically, PD patients, whether or not impaired on a mental status examination, had deficient Picture Arrangement but normal Vocabulary test scores whereas AD patients were impaired on both measures. Furthermore, PD patients with impaired mental status examination scores showed a deficit in set formation on Picture Arrangement not seen in the AD patients. Finally, when recent memory performance, as measured by the Wechsler Memory Scale, was predicted from an estimated IQ, 71% of PD patients who had normal mental status examination scores were seen to have at least a mild memory impairment.

摘要

帕金森病(PD)患者表现出与阿尔茨海默病(AD)所致痴呆患者不同的认知缺陷模式。具体而言,PD患者无论精神状态检查是否受损,图片排列测试得分较低,但词汇测试得分正常,而AD患者在这两项测试中均表现受损。此外,精神状态检查得分受损的PD患者在图片排列测试中的定势形成方面存在缺陷,而AD患者未出现这种情况。最后,当根据估计智商预测韦氏记忆量表所测量的近期记忆表现时,精神状态检查得分正常的PD患者中有71%被发现至少存在轻度记忆障碍。

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