Department of Neurosurgery, Kutahya Health Science University, Medical Faculty, Kutahya, Turkey.
Department of Radiology, Izmir Democracy University, Medical Faculty, Izmir, Turkey.
Curr Med Imaging. 2021;17(6):762-766. doi: 10.2174/1573405617666210303105006.
Peritumoral edema of primary brain tumors is an important cause of morbidity and mortality. The number of studies currently available on the prognostic role of peritumoral brain edema in the posterior fossa is extremely limited.
Based on the known importance of magnetic resonance imaging in diagnosing supratentorial metastases, this study aimed to investigate the effects of peritumoral edema on survival of patients with posterior fossa metastases and the preoperative diagnostic value of MRI.
Edema and mass volumes of 49 patients with posterior fossa metastasis, who underwent surgery during 2012-2016, were measured using magnetic resonance imaging. The edema/mass indices were retrospectively calculated and interpreted by evaluating the demographic, clinical, and survival data.
The study consisted of 32 (65.3%) male and 17 (34.7%) female participants, with the mean age ± standard deviation of 47.25±29.25 (17-81) years. Among the 49 patients with posterior fossa metastases, 34 (69.4%) had carcinoma, while 15 (30.6%) had non-carcinoma metastases. The edema/mass indices of patients with carcinoma and non-carcinoma metastases were found to be 14.55±9.64 and 1.34±1.08, respectively, and the difference was statistically significant (p<0.001). The mean survival of patients with carcinoma and non-carcinoma metastases was found to be 642±11.52 days and 726±9.32 days, respectively; however, this difference was not statistically significant (p=0.787).
The edema/mass ratio was found to be a significant diagnostic factor for the prediction of posterior fossa metastases. Further detailed studies are warranted to investigate the effect of edema/mass ratio on survival rate.
原发性脑肿瘤的瘤周水肿是发病率和死亡率的一个重要原因。目前关于后颅窝瘤周水肿的预后作用的研究数量极其有限。
基于磁共振成像在诊断幕上转移中的重要性，本研究旨在探讨后颅窝转移瘤瘤周水肿对患者生存的影响以及 MRI 的术前诊断价值。
对 2012-2016 年间接受手术治疗的 49 例后颅窝转移瘤患者的水肿和肿块体积进行磁共振成像测量。通过评估患者的人口统计学、临床和生存数据，回顾性计算并解释水肿/肿块指数。
本研究共纳入 32 例（65.3%）男性和 17 例（34.7%）女性患者，平均年龄±标准差为 47.25±29.25（17-81）岁。49 例后颅窝转移瘤患者中，34 例（69.4%）为癌转移，15 例（30.6%）为非癌转移。癌转移和非癌转移患者的水肿/肿块指数分别为 14.55±9.64 和 1.34±1.08，差异有统计学意义（p<0.001）。癌转移和非癌转移患者的平均生存时间分别为 642±11.52 天和 726±9.32 天，但差异无统计学意义（p=0.787）。
水肿/肿块比是预测后颅窝转移瘤的一个重要诊断因素。需要进一步的详细研究来探讨水肿/肿块比对生存率的影响。
