光谱仪和 Cirrus 光学相干断层扫描仪在检测不完全和完全性视网膜色素上皮和外层视网膜萎缩中的比较。
COMPARISON OF SPECTRALIS AND CIRRUS OPTICAL COHERENCE TOMOGRAPHY FOR THE DETECTION OF INCOMPLETE AND COMPLETE RETINAL PIGMENT EPITHELIUM AND OUTER RETINAL ATROPHY.
机构信息
Doheny Eye Institute, University of California at Los Angeles, Los Angeles, California.
Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California.
出版信息
Retina. 2021 Sep 1;41(9):1851-1857. doi: 10.1097/IAE.0000000000003158.
PURPOSE
To evaluate and compare the detection of incomplete and complete retinal pigment epithelial and outer retinal atrophy (iRORA and cRORA) using Spectralis and Cirrus optical coherence tomography (OCT) devices.
METHODS
Subjects with late age-related macular degeneration were imaged on the same day with Spectralis and Cirrus OCT. Two, masked, independent, and experienced retina specialist graders evaluated each case for the presence of cRORA and iRORA lesions.
RESULTS
A significantly higher number of lesions were observed using Spectralis compared with Cirrus (239 vs. 226 and 223 vs. 209). Higher number of iRORA lesions were identified with Spectralis (105 vs. 90 and 96 vs. 82), and no significant difference was observed between devices for cRORA lesions (134 vs. 136 and 128 vs. 126). When considering the presence or absence of iRORA or cRORA, the agreement between devices for both graders was excellent for cRORA and good for iRORA.
CONCLUSION
Spectralis and Cirrus OCT identified a similar number of cRORA lesions, although more iRORA lesions could be detected with Spectralis OCT. These findings may have implications for developing acquisition protocols for trials based on the intended atrophy targets and highlight the importance of using a consistent OCT instrument across a study.
目的
评估和比较 Spectralis 和 Cirrus 光学相干断层扫描（OCT）设备检测不完全性和完全性视网膜色素上皮和外层视网膜萎缩（iRORA 和 cRORA）的效果。
方法
对患有晚期年龄相关性黄斑变性的受试者在同一天使用 Spectralis 和 Cirrus OCT 进行成像。两名独立、经验丰富的视网膜专家对每个病例进行评估，以确定是否存在 cRORA 和 iRORA 病变。
结果
与 Cirrus 相比，Spectralis 观察到的病变数量明显更多（239 与 226 相比，223 与 209 相比）。Spectralis 识别出更多的 iRORA 病变（105 与 90 相比，96 与 82 相比），而在 cRORA 病变方面，两种设备之间没有观察到显著差异（134 与 136 相比，128 与 126 相比）。当考虑是否存在 iRORA 或 cRORA 时，两位评估者对两种设备的评估结果具有极好的一致性。
结论
Spectralis 和 Cirrus OCT 识别出的 cRORA 病变数量相似，但 Spectralis OCT 可以检测到更多的 iRORA 病变。这些发现可能对基于预期萎缩靶标制定试验采集方案具有影响，并强调了在研究中使用一致的 OCT 仪器的重要性。
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