Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China.
Medicine (Baltimore). 2021 Mar 5;100(9):e25025. doi: 10.1097/MD.0000000000025025.
This study aimed to investigate the correlation between triglyceride glucose (TyG) index and coronary artery disease (CAD) with type 2 diabetes mellitus (T2DM) and identify the risk associated TyG index in different subgroups.A total of 1665 eligible inpatients (CAD with T2DM group [n = 680], non-coronary artery disease without T2DM [n = 985]) were consecutively enrolled in this study. They were assigned into 4 subgroups: middle-aged, elderly, male, and female subgroups. Receiver operating characteristic curve diagnostic test and a logistic regression model was established to analyze the risk factors for CAD with T2DM.TyG index is an independent risk factor for patients with CAD with T2DM. The risk of increased TyG index is greater in the middle-aged and male subgroups than in the elderly and female subgroups, respectively (all P < .05). The specificity and the positive predictive value of the TyG index is greater than the sensitivity and the negative predictive value, respectively (all P < .05).Increased TyG index is a new independent risk factor for CAD with T2DM, and its risk is higher in the middle-aged and male subgroups than in the elderly and female subgroups, respectively. TyG index may be used as a clinical predictor of CAD with T2DM.
本研究旨在探讨甘油三酯-葡萄糖（TyG）指数与 2 型糖尿病（T2DM）合并冠心病（CAD）的相关性，并确定不同亚组中与 TyG 指数相关的风险。
这项研究纳入了 1665 名符合条件的住院患者（CAD 合并 T2DM 组 [n=680]，非 CAD 且无 T2DM 组 [n=985]）。他们被分为 4 个亚组：中年、老年、男性和女性亚组。采用受试者工作特征曲线诊断试验和逻辑回归模型分析 CAD 合并 T2DM 的危险因素。
TyG 指数是 CAD 合并 T2DM 患者的独立危险因素。与老年和女性亚组相比，中年和男性亚组 TyG 指数升高的风险分别更大（均 P<0.05）。TyG 指数的特异性和阳性预测值大于其敏感性和阴性预测值（均 P<0.05）。
TyG 指数升高是 CAD 合并 T2DM 的一个新的独立危险因素，其风险在中年和男性亚组中分别高于老年和女性亚组。TyG 指数可作为 CAD 合并 T2DM 的临床预测指标。
