Department of Molecular Biotechnologies and Health Sciences, Molecular Imaging Center, University of Torino, Via Nizza 52, 10126 Torino, Italy.
Chem Commun (Camb). 2021 Apr 4;57(26):3287-3290. doi: 10.1039/d1cc00366f. Epub 2021 Mar 3.
Eu(HP-DO3A) is present in solution as a mixture of two diastereoisomers whose alcoholic groups are the source of the mobile protons for the CEST effect. The exchange is base catalyzed. Two novel Eu complexes of HP-DO3A-like ligands containing an amino or a carboxylate functionality in the proximity of the -OH groups showed the occurrence of intramolecular catalysis of the prototropic exchange. New insights into the role of the intramolecular proton exchange on the CEST properties have been gained.
Eu(HP-DO3A)在溶液中以两种非对映异构体的混合物形式存在，其醇基团是 CEST 效应的可移动质子的来源。交换是碱催化的。两种新型的 Eu 配合物，HP-DO3A 类似配体在 -OH 基团附近含有氨基或羧基官能团，显示出质子交换的分子内催化作用的发生。对分子内质子交换对 CEST 性质的作用有了新的认识。
