Department of Drug Science and Technology, University of Torino, Via. P. Giuria 7, 10125 Torino, Italy.
Chem Commun (Camb). 2018 Sep 6;54(72):10056-10059. doi: 10.1039/c8cc05284k.
The Gd(iii)-complexes of three novel HP-DO3A-like ligands have been investigated to assess the relationship between relaxometry and intramolecular catalysis of the proton exchange. The structures of these ligands differ from the parent HP-DO3A because the methyl group of the hydroxy-propyl arm has been replaced by -Ph-OH, -Ph-NH2 and -Ph-COOH, respectively. The phenol, amine and carboxylate functionalities display an intramolecular H-bonding with the coordinated hydroxyl moiety that affects either the pK values of the involved functionalities and the rate of the proton exchange process.
研究了三种新型 HP-DO3A 类似配体的 Gd(iii)-配合物，以评估弛豫率与质子交换的分子内催化之间的关系。这些配体的结构与母体 HP-DO3A 不同，因为羟丙基臂的甲基分别被 -Ph-OH、-Ph-NH2 和 -Ph-COOH 取代。酚、胺和羧酸官能团与配位的羟基部分形成分子内氢键，这影响了涉及官能团的 pK 值和质子交换过程的速率。
