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运动障碍患者的描述性流行病学研究,重点是帕金森病。

Descriptive epidemiological study on patients with movement disorders, with emphasis on Parkinson's disease.

机构信息

MD, MSc. Neurologist, Department of Neurology, Hospital do Servidor Público Estadual (IAMSPE), São Paulo (SP), Brazil.

MD, PhD. Neurologist, Movement Disorders Unit, Department of Neurology, Universidade Federal de São Paulo (UNIFESP), São Paulo (SP), Brazil.

出版信息

Sao Paulo Med J. 2021 Jan-Feb;139(1):30-37. doi: 10.1590/1516-3180.2020.0119.R1.30102020.

DOI:10.1590/1516-3180.2020.0119.R1.30102020
PMID:33656125
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9632504/
Abstract

BACKGROUND

Knowing the epidemiological profile is relevant for improving healthcare practices. Movement disorders are neurological disorders characterized by the presence of involuntary movements. They have a negative impact on patients' quality of life.

OBJECTIVES

To outline the frequencies of the different diagnoses seen among patients, along with their demographic characteristics, at a hospital in São Paulo (SP), Brazil, and to highlight the clinical aspects of those with Parkinson's disease.

DESIGN AND SETTING

Retrospective descriptive epidemiological analysis at a specialized outpatient clinic in a state public hospital in São Paulo.

METHODS

Patients treated at this clinic over a four-year period were analyzed. Diagnoses, demographic variables and associations with clinical aspects of Parkinson's disease were evaluated.

RESULTS

Out of the 680 medical records analyzed, 58.4% related to females. Most patients were over 60 years of age, white, married and teachers. The most frequent diagnosis was Parkinson's disease, followed by essential tremor and dystonia. Parkinson's disease presented in the mixed clinical form; the most common initial symptom was tremor. The akinetic-rigid clinical form occurred in younger individuals and mostly presented with postural instability and freezing of gait in the early years of disease.

CONCLUSIONS

Parkinson's disease, essential tremor and dystonia were the most frequent diagnoses. Characteristics like sex, frequency of other pathological conditions and the clinical and demographic aspects of Parkinson's disease were consistent with the data in the relevant literature.

摘要

背景

了解流行病学特征对于改善医疗保健实践至关重要。运动障碍是一种以不自主运动为特征的神经障碍。它们对患者的生活质量有负面影响。

目的

概述巴西圣保罗一家医院患者的不同诊断的频率及其人口统计学特征,并强调帕金森病患者的临床特征。

设计和设置

在圣保罗州立公立医院的一家专门的门诊诊所进行回顾性描述性流行病学分析。

方法

对该诊所四年期间治疗的患者进行分析。评估了诊断、人口统计学变量以及与帕金森病临床特征的关联。

结果

在分析的 680 份病历中,58.4%与女性有关。大多数患者年龄在 60 岁以上,为白种人、已婚和教师。最常见的诊断是帕金森病,其次是原发性震颤和肌张力障碍。帕金森病呈混合临床形式;最常见的初始症状是震颤。无动性僵硬临床形式发生在年轻患者中,主要在疾病早期出现姿势不稳定和步态冻结。

结论

帕金森病、原发性震颤和肌张力障碍是最常见的诊断。性别等特征、其他病理情况的频率以及帕金森病的临床和人口统计学特征与相关文献中的数据一致。

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Methylation status of the PPP1R13L promoter region among lung cancer patients and healthy controls. Analytical cross-sectional study.肺癌患者和健康对照人群中PPP1R13L启动子区域的甲基化状态。分析性横断面研究。
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