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非囊性纤维化支气管扩张症患者运动诱导的低氧血症:实验室检测与现场运动试验比较。

Exercise-induced desaturation in subjects with non-cystic fibrosis bronchiectasis: laboratory-based tests versus field-based exercise tests.

机构信息

. Programa de Pós-Graduação em Ciências de Reabilitação, Universidade Nove de Julho, São Paulo (SP) Brasil.

. Programa de Pós-Graduação em Ciências de Reabilitação e Desempenho Físico-Funcional, Universidade Federal de Juiz de Fora, Juiz de Fora (MG) Brasil.

出版信息

J Bras Pneumol. 2021 Feb 24;47(2):e20200134. doi: 10.36416/1806-3756/e20200134. eCollection 2021.

DOI:10.36416/1806-3756/e20200134
PMID:33656157
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8332849/
Abstract

OBJECTIVE

To investigate the validity of field walking tests to identify exercise-induced hypoxemia and to compare cardiorespiratory responses and perceived effort between laboratory-based and field-based exercise tests in subjects with bronchiectasis.

METHODS

This was a cross-sectional study involving 72 non-oxygen-dependent participants (28 men; mean age = 48.3 ± 14.5 years; and mean FEV1 = 54.1 ± 23.4% of the predicted value). The participants underwent cardiopulmonary exercise testing (CPET) on a treadmill and constant work-rate exercise testing (CWRET) on the same day (1 h apart). In another visit, they underwent incremental shuttle walk testing (ISWT) and endurance shuttle walk testing (ESWT; 1 h apart). Desaturation was defined as a reduction in SpO2 ≥ 4% from rest to peak exercise.

RESULTS

CPET results were compared with ISWT results, as were CWRET results with ESWT results. There was no difference in the magnitude of desaturation between CPET and ISWT (-7.7 ± 6.3% vs. -6.6 ± 5.6%; p = 0.10) and between CWRET and ESWT (-6.8 ± 5.8% vs. -7.2 ± 6.3%; p = 0.50). The incremental tests showed an agreement in the magnitude of desaturation in the desaturation and no desaturation groups (42 and 14 participants, respectively; p < 0.01), as did the endurance tests (39 and 16 participants; p < 0.01). The magnitude of desaturation was similar among the participants who did or did not reach at least 85% of the maximum predicted HR.

CONCLUSIONS

Field exercise tests showed good precision to detect desaturation. Field tests might be an alternative to laboratory tests when the clinical question is to investigate exercise-induced desaturation in subjects with bronchiectasis.

摘要

目的

探究现场行走测试识别运动诱导性低氧血症的有效性,并比较支气管扩张症患者的实验室和现场运动测试的心肺反应和感知用力程度。

方法

这是一项横断面研究,涉及 72 名非吸氧依赖患者(28 名男性;平均年龄=48.3±14.5 岁;平均 FEV1=预测值的 54.1±23.4%)。这些患者在同一天(间隔 1 小时)进行跑步机心肺运动测试(CPET)和恒功率运动测试(CWRET)。在另一次就诊中,他们进行了递增式穿梭步行测试(ISWT)和耐力式穿梭步行测试(ESWT;间隔 1 小时)。低氧血症定义为 SpO2 从休息到峰值运动时下降≥4%。

结果

CPET 结果与 ISWT 结果进行了比较,CWRET 结果与 ESWT 结果也进行了比较。CPET 和 ISWT 之间的低氧血症程度差异无统计学意义(-7.7±6.3% vs. -6.6±5.6%;p=0.10),CWRET 和 ESWT 之间的低氧血症程度差异也无统计学意义(-6.8±5.8% vs. -7.2±6.3%;p=0.50)。在有和无低氧血症的递增试验中(分别为 42 名和 14 名参与者;p<0.01),以及在耐力试验中(分别为 39 名和 16 名参与者;p<0.01),低氧血症程度的一致性较好。在达到或未达到最大预测 HR 至少 85%的参与者中,低氧血症程度相似。

结论

现场运动测试在检测低氧血症方面具有较好的精度。当临床问题是调查支气管扩张症患者的运动诱导性低氧血症时,现场测试可能是实验室测试的替代方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2a/8332849/d68bc3039d1f/1806-3756-jbpneu-47-02-e20200134-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2a/8332849/d68bc3039d1f/1806-3756-jbpneu-47-02-e20200134-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f2a/8332849/d68bc3039d1f/1806-3756-jbpneu-47-02-e20200134-gf1.jpg

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本文引用的文献

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2
ERS statement on standardisation of cardiopulmonary exercise testing in chronic lung diseases.ERS 关于慢性肺部疾病心肺运动试验标准化的声明。
Eur Respir Rev. 2019 Dec 18;28(154). doi: 10.1183/16000617.0101-2018. Print 2019 Dec 31.
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An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease.
一项关于欧洲呼吸学会/美国胸科学会的官方系统评价:慢性呼吸疾病现场行走测试的测量特性。
Eur Respir J. 2014 Dec;44(6):1447-78. doi: 10.1183/09031936.00150414. Epub 2014 Oct 30.
4
An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease.一个官方的欧洲呼吸学会/美国胸科学会技术标准:慢性呼吸疾病的现场行走测试。
Eur Respir J. 2014 Dec;44(6):1428-46. doi: 10.1183/09031936.00150314. Epub 2014 Oct 30.
5
Pilot investigation of the oxygen demands and metabolic cost of incremental shuttle walking and treadmill walking in patients with cardiovascular disease.心血管疾病患者递增式往返步行和跑步机步行的需氧量及代谢成本的初步研究。
BMJ Open. 2014 Sep 16;4(9):e005216. doi: 10.1136/bmjopen-2014-005216.
6
Incremental shuttle walking test: a reproducible and valid test to evaluate exercise tolerance in adults with noncystic fibrosis bronchiectasis.递增往返步行试验:一种用于评估非囊性纤维化支气管扩张症成人运动耐量的可重复且有效的试验。
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7
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