Department of Chemistry, University of Pennsylvania, 231 S. 34th St., Philadelphia, PA 19104, USA.
Chem Rec. 2021 Apr;21(4):906-923. doi: 10.1002/tcr.202100017. Epub 2021 Mar 3.
The cyclopeptide alkaloids are cyclic depsipeptides incorporating cyclophanes with polyamide units 13-, 14- and 15-membered macrocyclic systems. Although various pharmacological activities have been ascribed to cyclopeptide alkaloids from plants of the Rhamnacea family, these studies have been hampered by their low availability due to the lack of reasonable amounts distributed in nature. Therefore, novel and efficient synthetic approaches should be an important aim, which inspired us to examine how to diversely construct the unique structures of this type of natural products. In this account, several typical strategies are presented in terms of efficient, stereocontrolled and regioselective synthesis of cyclopeptide alkaloids.
环肽生物碱是一种含有环芳烷的环二肽，具有 13、14 和 15 元大环的聚酰胺单元。尽管从鼠李科植物中分离出的环肽生物碱具有多种药理学活性，但由于在自然界中分布的数量有限，导致其可用性较低，这些研究受到了阻碍。因此，新颖有效的合成方法应该是一个重要的目标，这启发我们研究如何多样化地构建这类天然产物的独特结构。在本报告中，我们提出了几种典型的策略，以高效、立体控制和区域选择性的方式合成环肽生物碱。
