Martin William H C, Blechert Siegfried
Institut für Chemie, Technische Universität Berlin, Strasse des 17. Juni 135, D-10623 Berlin, Germany.
Curr Top Med Chem. 2005;5(15):1521-40. doi: 10.2174/156802605775009757.
Olefin metathesis has rapidly established itself as an essential tool in the synthetic chemist's armoury. The ease of operation and functional group tolerance that is obtained with the modern generation of catalysts makes the use of metathesis an extremely attractive option when preparing medicinally interesting molecules. This article will outline some of the ways in which chemists from both industry and academia have been utilising and developing metathesis in the search for novel biological probes and drug leads.
烯烃复分解反应已迅速成为合成化学家武器库中的一项重要工具。现代催化剂所具备的易于操作和对官能团的耐受性，使得在制备具有药用价值的分子时，使用复分解反应成为极具吸引力的选择。本文将概述工业界和学术界的化学家在寻找新型生物探针和药物先导物的过程中利用和发展复分解反应的一些方式。
