Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Lab Chip. 2021 Apr 20;21(8):1484-1491. doi: 10.1039/d0lc01327g.
Dispensing micron-scale droplets from a suspended nozzle is important for applications in bioprinting, analytical chemistry, and pharmaceutical formulation. Here, we describe a general approach to eject droplets from microfluidic devices using superhydrophobic patterning; this facilitates release of wetted fluids, allowing droplets to break contact with channel surfaces and travel along regular paths to achieve a printing accuracy of ∼3 μm. We demonstrate the utility of the approach by using it to print droplets of varied composition from a microfluidic mixing device. Our approach is compatible with common fabrication techniques making it applicable to devices configured for diverse applications.
从悬浮喷嘴分配微尺度液滴对于生物打印、分析化学和药物制剂等应用非常重要。在这里，我们描述了一种使用超疏水图案化从微流控设备中喷射液滴的通用方法；这有利于释放润湿的流体，使液滴与通道表面脱离接触，并沿着规则的路径行进，从而实现约 3 μm 的打印精度。我们通过使用该方法从小型混合设备中打印各种成分的液滴来证明该方法的实用性。我们的方法与常见的制造技术兼容，因此适用于各种应用配置的设备。
