Israel O, Front D, Lam M, Ben-Haim S, Kleinhaus U, Ben-Shachar M, Robinson E, Kolodny G M
Department of Nuclear Medicine, Rambam Medical Center, Haifa, Israel.
Cancer. 1988 Jun 15;61(12):2439-43. doi: 10.1002/1097-0142(19880615)61:12<2439::aid-cncr2820611208>3.0.co;2-q.
The value of gallium 67 (Ga) imaging in monitoring lymphoma response to treatment was assessed in 25 patients with Ga-avid tumors and compared to body computed tomography (CT), chest radiographs, and palpation of tumor infiltrated peripheral lymph nodes. Ga imaging was negative in 95% (20/21) of the patients who were clinically considered to be in remission and in whom treatment was stopped. The disease did not recur during a follow-up of 12 to 26 months in 15 patients. Six patients developed recurrence of the disease 3 to 12 months after treatment was stopped. In all six patients Ga imaging became positive again at the time of the appearance of active disease. In the group of patients in remission, CT was negative in 57% (11/19), chest x-rays in 55% (6/11) and peripheral lymph nodes were palpated in none of the patients (13/13). In four patients that did not achieve remission after treatment, Ga scans were positive. Ga imaging appears useful in monitoring lymphoma response to treatment. This is probably because Ga imaging monitors tumor cell viability, whereas body CT and chest radiographs show the tumor mass, which may consist of fibrotic or necrotic tissue.
对25例镓67（Ga）亲肿瘤患者的Ga显像在监测淋巴瘤治疗反应中的价值进行了评估，并与全身计算机断层扫描（CT）、胸部X线片以及对肿瘤浸润的外周淋巴结触诊进行比较。在临床判定为缓解且停止治疗的患者中，95%（20/21）的患者Ga显像为阴性。15例患者在12至26个月的随访期间疾病未复发。6例患者在停止治疗后3至12个月疾病复发。在所有6例患者中，在出现活动性疾病时Ga显像再次转为阳性。在缓解组患者中，CT检查阴性的占57%（11/19），胸部X线片阴性的占55%（6/11），所有患者（13/13）触诊外周淋巴结均未发现异常。在4例治疗后未缓解的患者中，Ga扫描为阳性。Ga显像似乎在监测淋巴瘤治疗反应方面很有用。这可能是因为Ga显像监测肿瘤细胞的活力，而全身CT和胸部X线片显示的是肿瘤肿块，其中可能包含纤维化或坏死组织。
