Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Basic Sciences in Infectious Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Adv Exp Med Biol. 2021;1321:115-126. doi: 10.1007/978-3-030-59261-5_10.
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly pathogenic with relatively high mortality and morbidity. In addition to pneumonia, acute respiratory distress syndrome, and microembolic disorder, a high proportion of patients with SARS-CoV-2 develop lymphopenia and cytokine storm disorder. This review explores the underlying mechanisms behind the pathogenesis of SARS-CoV-2, especially the immune mechanisms, which could be potentially used as therapeutic targets for the management of COVID-19.
由严重急性呼吸综合征冠状病毒 2 型（SARS-CoV-2）引起的 2019 年冠状病毒病（COVID-19）具有高致病性，死亡率和发病率相对较高。除了肺炎、急性呼吸窘迫综合征和微栓塞障碍外，相当一部分 SARS-CoV-2 患者还会出现淋巴细胞减少症和细胞因子风暴障碍。本综述探讨了 SARS-CoV-2 发病机制背后的潜在机制，特别是免疫机制，这些机制可能被用作 COVID-19 管理的治疗靶点。
